loading...| Preferred Name | Activated SYK Phosphorylates BLNK (SLP65) | |
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| Definitions |
has a Stoichiometric coefficient of 5 Edited: May, B, 2010-10-31 BLNK (SLP-65, BASH) forms a stable complex with GRB2, SOS1, and CIN85 in the cytosol. The complex is recruited to the plasma membrane where activated (phosphorylated) SYK phosphorylates BLNK at tyrosines 72, 84, 96, 178, and 189 (Fu et al. 1998, Chiu et al. 2002, inferred from mouse in Wienands et al. 1998, from chicken in Oellerich et al. 2009). Phosphorylated BLNK serves as a scaffold that binds effector molecules such as Phospholipase C. As inferred from mouse, BLNK interacts with phosphorylated tyrosines on CD79A (Ig-alpha) (Engels et al. 2001, Kabak et al. 2002). Reviewed: Wienands, J, 2012-02-11 Authored: May, B, 2010-10-31 |
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http://purl.obolibrary.org/obo/HINO_0017760 |
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| comment |
has a Stoichiometric coefficient of 5 Edited: May, B, 2010-10-31 BLNK (SLP-65, BASH) forms a stable complex with GRB2, SOS1, and CIN85 in the cytosol. The complex is recruited to the plasma membrane where activated (phosphorylated) SYK phosphorylates BLNK at tyrosines 72, 84, 96, 178, and 189 (Fu et al. 1998, Chiu et al. 2002, inferred from mouse in Wienands et al. 1998, from chicken in Oellerich et al. 2009). Phosphorylated BLNK serves as a scaffold that binds effector molecules such as Phospholipase C. As inferred from mouse, BLNK interacts with phosphorylated tyrosines on CD79A (Ig-alpha) (Engels et al. 2001, Kabak et al. 2002). Reviewed: Wienands, J, 2012-02-11 Authored: May, B, 2010-10-31 |
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| definition source |
Pubmed9697839 Pubmed19372136 Pubmed12456653 Pubmed9341187 Reactome, http://www.reactome.org Pubmed11909947 Pubmed11449366 Pubmed11071869 Pubmed9705962 Pubmed21822214 |
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http://purl.obolibrary.org/obo/HINO_0009207 |
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| label |
Activated SYK Phosphorylates BLNK (SLP65) |
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| prefixIRI |
HINO:0017760 |
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| prefLabel |
Activated SYK Phosphorylates BLNK (SLP65) |
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| seeAlso |
Reactome Database ID Release 43983703 EC Number: 2.7.10 ReactomeREACT_118834 |
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