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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0017755
http://purl.obolibrary.org/obo/HINO_0017755
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|---|---|
| Preferred Name | Phosphorylation of ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B) |
| Definitions |
has a Stoichiometric coefficient of 4
Edited: May, B, 2010-09-28
The B cell receptor (BCR) comprises an immunoglobulin complexed with a heterodimer of Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29). After immunoglobulin IgM or IgD binds antigen the associated Ig-alpha and Ig-beta are each observed to be phosphorylated at two tyrosine residues in the cytoplasmic immunoreceptor tyrosine-activated motif (ITAM) (Sanchez et al. 1993, Hata et al. 1994, Saouaf et al. 1994, Saouaf et al. 1995). Saouaf et al. (1995) showed that the kinase Blk could phosphorylate both tyrosines of each ITAM and that the kinase SYK specifically bound phosphorylated but not unphosphorylated ITAMs. In mouse the kinase Lyn and other kinases phosphorylate one tyrosine and Syk is believed to phosphorylate the other (Yamanashi et al. 1991, Flaswinkel and Reth 1994, Rolli et al. 2002).
Reviewed: Wienands, J, 2012-02-11
Authored: May, B, 2010-09-28
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Phosphorylation of ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)
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|---|---|
| comment |
has a Stoichiometric coefficient of 4
Edited: May, B, 2010-09-28
The B cell receptor (BCR) comprises an immunoglobulin complexed with a heterodimer of Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29). After immunoglobulin IgM or IgD binds antigen the associated Ig-alpha and Ig-beta are each observed to be phosphorylated at two tyrosine residues in the cytoplasmic immunoreceptor tyrosine-activated motif (ITAM) (Sanchez et al. 1993, Hata et al. 1994, Saouaf et al. 1994, Saouaf et al. 1995). Saouaf et al. (1995) showed that the kinase Blk could phosphorylate both tyrosines of each ITAM and that the kinase SYK specifically bound phosphorylated but not unphosphorylated ITAMs. In mouse the kinase Lyn and other kinases phosphorylate one tyrosine and Syk is believed to phosphorylate the other (Yamanashi et al. 1991, Flaswinkel and Reth 1994, Rolli et al. 2002).
Reviewed: Wienands, J, 2012-02-11
Authored: May, B, 2010-09-28
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| prefLabel |
Phosphorylation of ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)
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| definition source |
Pubmed8306975
Reactome, http://www.reactome.org
Pubmed7688784
Pubmed7524079
Pubmed7927516
Pubmed7592958
Pubmed12453414
Pubmed1702903
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| prefixIRI |
HINO:0017755
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| seeAlso |
ReactomeREACT_118716
EC Number: 2.7.10
Reactome Database ID Release 43983709
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| subClassOf | |
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| has input | |
| has output |
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