Human Interaction Network Ontology

Last uploaded: June 27, 2014
Preferred Name

BLNK (SLP-65) Signalosome Generates Diacylglycerol and Inositol-1,4,5-trisphosphate
Synonyms
Definitions

Edited: May, B, 2011-01-19 Phospholipase C gamma (PLC-gamma) is activated by phosphorylation in response to antigen-binding by the B cell receptor (Carter et al. 1991, Roitman and Wang 1992, Rodriguez et al. 2001, Kim et al. 2004, Sekiya et al. 2004). Phospholipase C gamma hydrolyzes phosphatidylinositol-4,5-bisphosphate to yield inositol-1,4,5-trisphosphate and diacylglycerol (Carter et al. 1991, Kim et al. 2004). Human B cells contain both PLC-gamma1 and PLC-gamma2, with PLC-gamma2 predominating (Coggeshall et al. 1992). Authored: May, B, 2011-01-19 Reviewed: Wienands, J, 2012-02-11

ID

http://purl.obolibrary.org/obo/HINO_0017739

comment

Edited: May, B, 2011-01-19

Phospholipase C gamma (PLC-gamma) is activated by phosphorylation in response to antigen-binding by the B cell receptor (Carter et al. 1991, Roitman and Wang 1992, Rodriguez et al. 2001, Kim et al. 2004, Sekiya et al. 2004). Phospholipase C gamma hydrolyzes phosphatidylinositol-4,5-bisphosphate to yield inositol-1,4,5-trisphosphate and diacylglycerol (Carter et al. 1991, Kim et al. 2004). Human B cells contain both PLC-gamma1 and PLC-gamma2, with PLC-gamma2 predominating (Coggeshall et al. 1992).

Authored: May, B, 2011-01-19

Reviewed: Wienands, J, 2012-02-11

definition source

Pubmed12181444

Pubmed1374290

Reactome, http://www.reactome.org

Pubmed1599430

Pubmed3500860

Pubmed1376928

Pubmed2011584

Pubmed1705565

has input

http://purl.obolibrary.org/obo/CHEBI_18348

has output

http://purl.obolibrary.org/obo/CHEBI_17815

http://purl.obolibrary.org/obo/CHEBI_16595

label

BLNK (SLP-65) Signalosome Generates Diacylglycerol and Inositol-1,4,5-trisphosphate

prefixIRI

HINO:0017739

prefLabel

BLNK (SLP-65) Signalosome Generates Diacylglycerol and Inositol-1,4,5-trisphosphate

seeAlso

Reactome Database ID Release 431112666

ReactomeREACT_118781

subClassOf

http://purl.obolibrary.org/obo/INO_0000040

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