loading...| Preferred Name | Destabilization of mRNA by KSRP | |
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| Definitions |
KSRP binds to AU-rich sequences in the 3' untranslated regions of mRNAs. KSRP causes the bound mRNA to be targeted for hydrolysis by recruiting exonucleases and decapping enzymes. The activity of KSRP is regulated by phosphorylation. Protein kinase B/Akt phosphorylates KSRP at serine193. The phosphorylation inhibits the ability of KSRP to destabilize mRNA. KSRP phosphorylated at serine193 binds 14-3-3zeta which causes KSRP to be retained in the nucleus. Reviewed: Wilusz, J, 2010-06-29 Authored: May, B, 2009-12-29 Edited: May, B, 2009-12-29 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0016714 |
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| comment |
KSRP binds to AU-rich sequences in the 3' untranslated regions of mRNAs. KSRP causes the bound mRNA to be targeted for hydrolysis by recruiting exonucleases and decapping enzymes. The activity of KSRP is regulated by phosphorylation. Protein kinase B/Akt phosphorylates KSRP at serine193. The phosphorylation inhibits the ability of KSRP to destabilize mRNA. KSRP phosphorylated at serine193 binds 14-3-3zeta which causes KSRP to be retained in the nucleus. Reviewed: Wilusz, J, 2010-06-29 Authored: May, B, 2009-12-29 Edited: May, B, 2009-12-29 |
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| definition source |
Pubmed16391004 Reactome, http://www.reactome.org Pubmed12704645 Pubmed12440953 |
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| label |
Destabilization of mRNA by KSRP |
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| located_in | ||
| prefixIRI |
HINO:0016714 |
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| prefLabel |
Destabilization of mRNA by KSRP |
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| seeAlso |
ReactomeREACT_25042 Reactome Database ID Release 43450604 |
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| has_part |
http://purl.obolibrary.org/obo/HINO_0015615 http://purl.obolibrary.org/obo/HINO_0015613 http://purl.obolibrary.org/obo/HINO_0015614 |