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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0016713
http://purl.obolibrary.org/obo/HINO_0016713
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|---|---|
| Preferred Name | Destabilization of mRNA by Tristetraprolin (TTP) |
| Definitions |
Tristetraproline (TTP) binds RNAs that contain AU-rich elements and recruits enzymes that degrade RNA. TTP interacts with the exosome (3' to 5' exonuclease), XRN1 (5' to 3' exonuclease), and the decapping enzymes DCP1 and DCP2a.<br>The activity of TTP is regulated by phosphorylation. MK2 phosphorylates TTP, which then binds 14-3-3.The interaction with 14-3-3 prevents phosphorylated TTP from entering stress granules and stabilizes mRNA bound by phosphorylated TTP. Tristetraproline is known to bind AU-rich elements in the following mRNAs: Tumor necrosis factor alpha (TNFA), Granulocyte-macrophage colony stimulating factor (CSF2, GM-CSF), Interleukin-2 (IL-2), and Proto-oncogene C-FOS (FOS, c-fos). Mice deficient in TTP exhibit arthritis, weight loss, skin lesions, autoimmunity, and myeloid hyperplasia.
Reviewed: Wilusz, J, 2010-06-29
Authored: May, B, 2009-12-29
Edited: May, B, 2009-12-29
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Destabilization of mRNA by Tristetraprolin (TTP)
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| comment |
Tristetraproline (TTP) binds RNAs that contain AU-rich elements and recruits enzymes that degrade RNA. TTP interacts with the exosome (3' to 5' exonuclease), XRN1 (5' to 3' exonuclease), and the decapping enzymes DCP1 and DCP2a.<br>The activity of TTP is regulated by phosphorylation. MK2 phosphorylates TTP, which then binds 14-3-3.The interaction with 14-3-3 prevents phosphorylated TTP from entering stress granules and stabilizes mRNA bound by phosphorylated TTP. Tristetraproline is known to bind AU-rich elements in the following mRNAs: Tumor necrosis factor alpha (TNFA), Granulocyte-macrophage colony stimulating factor (CSF2, GM-CSF), Interleukin-2 (IL-2), and Proto-oncogene C-FOS (FOS, c-fos). Mice deficient in TTP exhibit arthritis, weight loss, skin lesions, autoimmunity, and myeloid hyperplasia.
Reviewed: Wilusz, J, 2010-06-29
Authored: May, B, 2009-12-29
Edited: May, B, 2009-12-29
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| prefLabel |
Destabilization of mRNA by Tristetraprolin (TTP)
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| located_in | |
| definition source |
Pubmed18481987
Pubmed16391004
Reactome, http://www.reactome.org
Pubmed12704645
Pubmed12440953
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| prefixIRI |
HINO:0016713
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| seeAlso |
Reactome Database ID Release 43450513
ReactomeREACT_25064
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| subClassOf | |
| type | |
| has_part |
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