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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S | |
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| Definitions |
The cap-binding complex is constituted by the initiation factors eIF4A, eIF4G and eIF4E. First, eIF4E must be released from the inactive eIF4E:4E-BP complex. Then eIF4A interacts with eIF4G, and eIF4E binds to the amino-terminal domain of eIF4G, resulting in the formation of the cap-binding complex eIF4F. eIF4A together with eIF4B or eIF4H is thought to unwind RNA secondary structures near the 5'-end of the mRNA. The translation initiation complex is formed when the 43S complex binds the cap-bound mRNA. |
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| ID |
http://purl.obolibrary.org/obo/HINO_0016702 |
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| comment |
The cap-binding complex is constituted by the initiation factors eIF4A, eIF4G and eIF4E. First, eIF4E must be released from the inactive eIF4E:4E-BP complex. Then eIF4A interacts with eIF4G, and eIF4E binds to the amino-terminal domain of eIF4G, resulting in the formation of the cap-binding complex eIF4F. eIF4A together with eIF4B or eIF4H is thought to unwind RNA secondary structures near the 5'-end of the mRNA. The translation initiation complex is formed when the 43S complex binds the cap-bound mRNA.
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| definition source |
Reactome, http://www.reactome.org Pubmed641056 Pubmed9732867 Pubmed592399 Pubmed6853548
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| label |
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
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| prefixIRI |
HINO:0016702
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| prefLabel |
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
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| seeAlso |
ReactomeREACT_1258 Reactome Database ID Release 4372662
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| subClassOf | ||
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http://purl.obolibrary.org/obo/HINO_0014807 http://purl.obolibrary.org/obo/HINO_0014812 http://purl.obolibrary.org/obo/HINO_0014811 |
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