loading...| Preferred Name | GTP hydrolysis and joining of the 60S ribosomal subunit | |
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| Definitions |
Hydrolysis of eIF2-GTP occurs after the Met-tRNAi has recognized the AUG. This reaction is catalyzed by eIF5 (or eIF5B) and is thought to cause dissociation of all other initiation factors and allow joining of the large 60S ribosomal subunit. The 60S subunit joins - a reaction catalyzed by eIF5 or eIF5B - resulting in a translation-competent 80S ribosome. Following 60S subunit joining, eIF5B hydrolyzes its GTP and is released from the 80S ribosome, which is now ready to start elongating the polypeptide chain. |
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| ID |
http://purl.obolibrary.org/obo/HINO_0016696 |
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| comment |
Hydrolysis of eIF2-GTP occurs after the Met-tRNAi has recognized the AUG. This reaction is catalyzed by eIF5 (or eIF5B) and is thought to cause dissociation of all other initiation factors and allow joining of the large 60S ribosomal subunit. The 60S subunit joins - a reaction catalyzed by eIF5 or eIF5B - resulting in a translation-competent 80S ribosome. Following 60S subunit joining, eIF5B hydrolyzes its GTP and is released from the 80S ribosome, which is now ready to start elongating the polypeptide chain. |
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| definition source |
Pubmed11018020 Pubmed1095581 Pubmed429297 Pubmed1856230 Reactome, http://www.reactome.org Pubmed641056 Pubmed10659855 Pubmed592399 Pubmed592398 |
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| label |
GTP hydrolysis and joining of the 60S ribosomal subunit |
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| located_in | ||
| prefixIRI |
HINO:0016696 |
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| prefLabel |
GTP hydrolysis and joining of the 60S ribosomal subunit |
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| seeAlso |
ReactomeREACT_2085 Reactome Database ID Release 4372706 |
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| subClassOf | ||
| has_part |
http://purl.obolibrary.org/obo/HINO_0014824 |