Link to this page
Human Interaction Network Ontology
Last uploaded:
June 27, 2014
Jump to:
| Preferred Name | mRNA Decay by 3' to 5' Exoribonuclease | |
| Synonyms |
|
|
| Definitions |
The degradation of mRNA from 3' to 5' occurs in two steps. First, the exosome exoribonuclease complex binds the 3' end of the oligoadenylated mRNA and hydrolyzes it from 3' to 5', yielding ribonucleotides having 5'-monophosphates, until a capped oligoribonucleotide remains. Second, the scavenging decapping enzyme DCPS hydrolyzes the 7-methylguanosine cap. Edited: May, B, 2009-07-22 Reviewed: Wilusz, J, 2009-09-17 Authored: May, B, 2009-07-22 |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0016669 |
|
| comment |
The degradation of mRNA from 3' to 5' occurs in two steps. First, the exosome exoribonuclease complex binds the 3' end of the oligoadenylated mRNA and hydrolyzes it from 3' to 5', yielding ribonucleotides having 5'-monophosphates, until a capped oligoribonucleotide remains. Second, the scavenging decapping enzyme DCPS hydrolyzes the 7-methylguanosine cap. Edited: May, B, 2009-07-22 Reviewed: Wilusz, J, 2009-09-17 Authored: May, B, 2009-07-22
|
|
| definition source |
Pubmed11283721 Pubmed15475613 Pubmed16141059 Reactome, http://www.reactome.org Pubmed14749774 Pubmed17245413 Pubmed19239894
|
|
| label |
mRNA Decay by 3' to 5' Exoribonuclease
|
|
| located_in | ||
| prefixIRI |
HINO:0016669
|
|
| prefLabel |
mRNA Decay by 3' to 5' Exoribonuclease
|
|
| seeAlso |
ReactomeREACT_20619 GENE ONTOLOGYGO:0043928 Reactome Database ID Release 43429958
|
|
| subClassOf | ||
| has_part |
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |