Deadenylation of mRNA proceeds in two steps. According to current models, in the first step the poly(A) tail is shortened from about 200 adenosine residues to about 80 residues by the PAN2-PAN3 complex. In the second step the poly(A) tail is further shortened to 10-15 residues by either the CCR4-NOT complex or by the PARN exoribonuclease. How a particular mRNA is targeted to CCR4-NOT or PARN is unknown.<br>A number of other deadenylase enzymes can be identified in genomic searches. One particularly interesting one is nocturin, a protein that is related to the CCR-1 deadenylase and plays a role in circadian rhythms.<br>There is also evidence for networking between deadenylation and other aspects of gene expression. CCR4-NOT, for example, is known to be a transcription factor. PARN is part of a complex that regulates poly(A) tail length and hence translation in developing oocytes. Edited: May, B, 2009-07-22 Reviewed: Wilusz, J, 2009-09-17 Authored: May, B, 2009-07-22

http://purl.obolibrary.org/obo/HINO_0016668

Deadenylation of mRNA proceeds in two steps. According to current models, in the first step the poly(A) tail is shortened from about 200 adenosine residues to about 80 residues by the PAN2-PAN3 complex. In the second step the poly(A) tail is further shortened to 10-15 residues by either the CCR4-NOT complex or by the PARN exoribonuclease. How a particular mRNA is targeted to CCR4-NOT or PARN is unknown.
A number of other deadenylase enzymes can be identified in genomic searches. One particularly interesting one is nocturin, a protein that is related to the CCR-1 deadenylase and plays a role in circadian rhythms.
There is also evidence for networking between deadenylation and other aspects of gene expression. CCR4-NOT, for example, is known to be a transcription factor. PARN is part of a complex that regulates poly(A) tail length and hence translation in developing oocytes.

Edited: May, B, 2009-07-22

Reviewed: Wilusz, J, 2009-09-17

Authored: May, B, 2009-07-22

Pubmed11283721

Pubmed15475613

Pubmed16141059

Reactome, http://www.reactome.org

Pubmed18608124

Pubmed17052452

Pubmed14749774

Pubmed17245413

Pubmed19239894

Deadenylation of mRNA

http://purl.obolibrary.org/obo/NCBITaxon_9606

HINO:0016668

Deadenylation of mRNA

GENE ONTOLOGYGO:0000289

Reactome Database ID Release 43429947

ReactomeREACT_20514

http://purl.obolibrary.org/obo/INO_0000021

http://purl.obolibrary.org/obo/HINO_0015254

http://purl.obolibrary.org/obo/HINO_0015259

http://purl.obolibrary.org/obo/HINO_0015255