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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | |
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| Definitions |
Authored: Orlic-Milacic, M, 2012-04-04 Reviewed: Huang, Tao, 2012-05-14 In the nucleus, SMAD2/3:SMAD4 heterotrimer complex acts as a transcriptional regulator. The activity of SMAD2/3 complex is regulated both positively and negatively by association with other transcription factors (Chen et al. 2002, Varelas et al. 2008, Stroschein et al. 1999, Wotton et al. 1999) . In addition, the activity of SMAD2/3:SMAD4 complex can be inhibited by nuclear protein phosphatases and ubiquitin ligases (Lin et al. 2006, Dupont et al. 2009). Edited: Jassal, B, 2012-04-10 |
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http://purl.obolibrary.org/obo/HINO_0016622 |
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| comment |
Authored: Orlic-Milacic, M, 2012-04-04 Reviewed: Huang, Tao, 2012-05-14 In the nucleus, SMAD2/3:SMAD4 heterotrimer complex acts as a transcriptional regulator. The activity of SMAD2/3 complex is regulated both positively and negatively by association with other transcription factors (Chen et al. 2002, Varelas et al. 2008, Stroschein et al. 1999, Wotton et al. 1999) . In addition, the activity of SMAD2/3:SMAD4 complex can be inhibited by nuclear protein phosphatases and ubiquitin ligases (Lin et al. 2006, Dupont et al. 2009). Edited: Jassal, B, 2012-04-10
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| definition source |
Pubmed18568018 Pubmed10531062 Reactome, http://www.reactome.org Pubmed12150994 Pubmed19135894 Pubmed16751101 Pubmed10199400
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Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
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HINO:0016622
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Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
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Reactome Database ID Release 432173793 GENE ONTOLOGYGO:0006351 ReactomeREACT_121061
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