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Human Interaction Network Ontology
| Preferred Name | YAP1- and WWTR1 (TAZ)-stimulated gene expression | |
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| Definitions |
Reviewed: Sudol, M, 2012-02-03 Edited: D'Eustachio, P, 2012-01-06 YAP1 and WWTR1 (TAZ) are transcriptional co-activators, both homologues of the Drosophila Yorkie protein. They both interact with members of the TEAD family of transcription factors, and WWTR1 interacts as well with TBX5 and RUNX2, to promote gene expression. Their transcriptional targets include genes critical to regulation of cell proliferation and apoptosis. Their subcellular location is regulated by the Hippo signaling cascade: phosphorylation mediated by this cascade leads to the cytosolic sequestration of both proteins (Murakami et al. 2005; Oh and Irvine 2010). Authored: D'Eustachio, P, 2012-02-03 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0016621 |
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| comment |
Reviewed: Sudol, M, 2012-02-03 Edited: D'Eustachio, P, 2012-01-06 YAP1 and WWTR1 (TAZ) are transcriptional co-activators, both homologues of the Drosophila Yorkie protein. They both interact with members of the TEAD family of transcription factors, and WWTR1 interacts as well with TBX5 and RUNX2, to promote gene expression. Their transcriptional targets include genes critical to regulation of cell proliferation and apoptosis. Their subcellular location is regulated by the Hippo signaling cascade: phosphorylation mediated by this cascade leads to the cytosolic sequestration of both proteins (Murakami et al. 2005; Oh and Irvine 2010). Authored: D'Eustachio, P, 2012-02-03
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| definition source |
Reactome, http://www.reactome.org Pubmed16332960 Pubmed20452772
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| label |
YAP1- and WWTR1 (TAZ)-stimulated gene expression
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| prefixIRI |
HINO:0016621
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| prefLabel |
YAP1- and WWTR1 (TAZ)-stimulated gene expression
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| seeAlso |
Reactome Database ID Release 432032785 ReactomeREACT_118713 GENE ONTOLOGYGO:0006367
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http://purl.obolibrary.org/obo/HINO_0015248 http://purl.obolibrary.org/obo/HINO_0019754 http://purl.obolibrary.org/obo/HINO_0019753 http://purl.obolibrary.org/obo/HINO_0019751 |
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