loading...| Preferred Name | RNA Polymerase I Transcription Initiation | |
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| Definitions |
Authored: Comai, L, 2003-07-03 17:13:29 Edited: Gillespie, ME, 0000-00-00 00:00:00 During initiation the double-stranded DNA must be melted and transcription begins. SL1 forms and interacts with UBF-1 and the rDNA promoter. It is this platform that will recruit active RNA polymerase I to the SL1:phosphorlated UBF-1:rDNA promoter complex.<p>Mammalian rRNA genes are preceded by a terminator element that is recognized by the SL1 complex. This SL1 modulated acetylation of the basal Pol I transcription machinery has functional consequences suggesting that the reversible acetylation may be one way to regulate rDNA transcription. |
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| ID |
http://purl.obolibrary.org/obo/HINO_0016618 |
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| comment |
Authored: Comai, L, 2003-07-03 17:13:29 Edited: Gillespie, ME, 0000-00-00 00:00:00 During initiation the double-stranded DNA must be melted and transcription begins. SL1 forms and interacts with UBF-1 and the rDNA promoter. It is this platform that will recruit active RNA polymerase I to the SL1:phosphorlated UBF-1:rDNA promoter complex. Mammalian rRNA genes are preceded by a terminator element that is recognized by the SL1 complex. This SL1 modulated acetylation of the basal Pol I transcription machinery has functional consequences suggesting that the reversible acetylation may be one way to regulate rDNA transcription. |
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| definition source |
Reactome, http://www.reactome.org |
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| label |
RNA Polymerase I Transcription Initiation |
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| prefixIRI |
HINO:0016618 |
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| prefLabel |
RNA Polymerase I Transcription Initiation |
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| seeAlso |
GENE ONTOLOGYGO:0006361 ReactomeREACT_953 Reactome Database ID Release 4373762 |
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| has_part |
http://purl.obolibrary.org/obo/HINO_0015814 http://purl.obolibrary.org/obo/HINO_0015813 http://purl.obolibrary.org/obo/HINO_0015748 http://purl.obolibrary.org/obo/HINO_0015825 |