loading...| Preferred Name | Homologous recombination repair of replication-independent double-strand breaks | |
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| Definitions |
Homologous recombination repair of replication-independent double-strand breaks requires the activation of ATM followed by ATM mediated phosphorylation of DNA repair proteins. DNA repair and signaling proteins are then recruited to double-strand breaks. The ends of the DNA double strand breaks must be resectioned and RPA complexes associate with the resulting ssDNA. Homologous DNA pairing and strand exchange then occurs followed by DNA repair synthesis and resolution of D-loop structures. |
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| ID |
http://purl.obolibrary.org/obo/HINO_0016460 |
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| comment |
Homologous recombination repair of replication-independent double-strand breaks requires the activation of ATM followed by ATM mediated phosphorylation of DNA repair proteins. DNA repair and signaling proteins are then recruited to double-strand breaks. The ends of the DNA double strand breaks must be resectioned and RPA complexes associate with the resulting ssDNA. Homologous DNA pairing and strand exchange then occurs followed by DNA repair synthesis and resolution of D-loop structures. |
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| definition source |
Reactome, http://www.reactome.org |
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| label |
Homologous recombination repair of replication-independent double-strand breaks |
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| located_in | ||
| prefixIRI |
HINO:0016460 |
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| prefLabel |
Homologous recombination repair of replication-independent double-strand breaks |
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| seeAlso |
ReactomeREACT_1587 Reactome Database ID Release 4373951 |
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| subClassOf | ||
| has_part |
http://purl.obolibrary.org/obo/HINO_0016470 http://purl.obolibrary.org/obo/HINO_0025052 http://purl.obolibrary.org/obo/HINO_0016484 http://purl.obolibrary.org/obo/HINO_0016492 |