loading...| Preferred Name | Signaling by FGFR2 amplification mutants | |
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Edited: Rothfels, K, 2012-05-16 FGFR2 amplifications have been identified in 10% of gastric cancers, where they are associated with poor prognosis diffuse cancers (Hattori, 1996; Ueda, 1999; Shin, 2000; Kunii, 2008) , and in ~1% of breast cancers (Turner, 2010; Tannheimer, 2000). FGFR2 amplification often occur in conjunction with deletions of C-terminal exons, resulting in expression of a internalization- and degradation-resistant form of the receptor (Takeda, 1999; Cha, 2008, 2009). Amplification affects signaling without altering the intrinsic kinase activity of the receptor. Signaling through overexpressed FGFR2 also shows evidence of being ligand-independent and sensitive to FGFR inhibitors (Lorenzi, 1997; Takeda, 1999; Cha, 2009). Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
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http://purl.obolibrary.org/obo/HINO_0016284 |
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Edited: Rothfels, K, 2012-05-16 FGFR2 amplifications have been identified in 10% of gastric cancers, where they are associated with poor prognosis diffuse cancers (Hattori, 1996; Ueda, 1999; Shin, 2000; Kunii, 2008) , and in ~1% of breast cancers (Turner, 2010; Tannheimer, 2000). FGFR2 amplification often occur in conjunction with deletions of C-terminal exons, resulting in expression of a internalization- and degradation-resistant form of the receptor (Takeda, 1999; Cha, 2008, 2009). Amplification affects signaling without altering the intrinsic kinase activity of the receptor. Signaling through overexpressed FGFR2 also shows evidence of being ligand-independent and sensitive to FGFR inhibitors (Lorenzi, 1997; Takeda, 1999; Cha, 2009). Authored: Rothfels, K, 2012-02-09 Reviewed: Ezzat, S, 2012-05-15 |
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| definition source |
Pubmed11003564 Pubmed9266968 Pubmed11056689 Pubmed18337450 Pubmed17505008 Pubmed10626794 Reactome, http://www.reactome.org Pubmed9816310 Pubmed20101236 Pubmed18381441 Pubmed19103595 |
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Signaling by FGFR2 amplification mutants |
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HINO:0016284 |
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Signaling by FGFR2 amplification mutants |
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ReactomeREACT_121255 Reactome Database ID Release 432023837 |
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http://purl.obolibrary.org/obo/HINO_0008093 http://purl.obolibrary.org/obo/HINO_0008098 |