loading...| Preferred Name | MPS IIIB - Sanfilippo syndrome B | |
| Synonyms |
|
|
| Definitions |
Reviewed: Coutinho, Maria, 2012-08-27 Authored: Jassal, B, 2012-04-26 Reviewed: Matos, Liliana, 2012-08-27 Mucopolysaccharidosis III (Sanfilippo syndrome) was described in 1963 by a pediatrician named Sylvester Sanfilippo (J. Pediat. 63: 837838, 1963, no reference). MPS IIIB (Mucopolysaccharidosis type IIIB, MPS IIIB, Sanfilippo syndrome type B; MIM:252920) is an autosomal recessive genetic disorder due to loss of function of alpha-N-acetylglucosaminidase (NAGLU; MIM:609701), involved in the hydrolysis of terminal non-reducing N-acetylglucosamine residues in heparan sulfate (HS) The gene encoding NAGLU was cloned in 1996 by Zhao and colleagues. It contains 6 exons and spans 8.3 kb on chromosome 17q21 (Zhao et al. 1996). MPSIIIB is characterized by severe CNS retardation but only mild somatic disease and death usually occurs in the second or third decade of life (Zhao et al. 1996, Yogalingam & Hopwood 2001, de Ruijter et al. 2011). MPS IIIB shows extensive molecular heterogeneity (Schmidtchen et al. 1998). Edited: Jassal, B, 2012-04-26 Reviewed: Alves, Sandra, 2012-08-27 |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0016266 |
|
| comment |
Reviewed: Coutinho, Maria, 2012-08-27 Authored: Jassal, B, 2012-04-26 Reviewed: Matos, Liliana, 2012-08-27 Mucopolysaccharidosis III (Sanfilippo syndrome) was described in 1963 by a pediatrician named Sylvester Sanfilippo (J. Pediat. 63: 837838, 1963, no reference). MPS IIIB (Mucopolysaccharidosis type IIIB, MPS IIIB, Sanfilippo syndrome type B; MIM:252920) is an autosomal recessive genetic disorder due to loss of function of alpha-N-acetylglucosaminidase (NAGLU; MIM:609701), involved in the hydrolysis of terminal non-reducing N-acetylglucosamine residues in heparan sulfate (HS) The gene encoding NAGLU was cloned in 1996 by Zhao and colleagues. It contains 6 exons and spans 8.3 kb on chromosome 17q21 (Zhao et al. 1996). MPSIIIB is characterized by severe CNS retardation but only mild somatic disease and death usually occurs in the second or third decade of life (Zhao et al. 1996, Yogalingam & Hopwood 2001, de Ruijter et al. 2011). MPS IIIB shows extensive molecular heterogeneity (Schmidtchen et al. 1998). Edited: Jassal, B, 2012-04-26 Reviewed: Alves, Sandra, 2012-08-27 |
|
| definition source |
Pubmed9443878 Reactome, http://www.reactome.org Pubmed21235449 Pubmed8650226 Pubmed11668611 |
|
| label |
MPS IIIB - Sanfilippo syndrome B |
|
| located_in | ||
| prefixIRI |
HINO:0016266 |
|
| prefLabel |
MPS IIIB - Sanfilippo syndrome B |
|
| seeAlso |
ReactomeREACT_147788 Reactome Database ID Release 432206282 |
|
| subClassOf | ||
| has_part |