loading...| Preferred Name | MPS IIIC - Sanfilippo syndrome C | |
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Reviewed: Coutinho, Maria, 2012-08-27 Authored: Jassal, B, 2012-04-26 Reviewed: Matos, Liliana, 2012-08-27 Mucopolysaccharidosis III (Sanfilippo syndrome) was described in 1963 by a pediatrician named Sylvester Sanfilippo (J. Pediat. 63: 837838, 1963, no reference). Mucopolysaccharidosis type IIIC (MPS IIIC, Sanfilippo syndrome C; MIM:252930) is an autosomal recessive genetic disorder due to the loss of heparan alpha-glucosaminide N-acetyltransferase (HGSNAT; MIM:610453) that normally acetylates the non-reducing terminal alpha-glucosamine residue of heparan sulfate. The molecular defects underlying MPS IIIC remained unknown for almost three decades due to the low tissue content and instability of HGSNAT. But, during the last decade, the gene was cloned in parallel by two different groups and shown to contain 18 exons and span approximately 62Kb (Fan et al. 2006, Hrebicek et al. 2006). Loss of HGSNAT results in build up of this glycosaminglycan (GAG) in cells and tissues and is characterized by severe central nervous system degeneration but only with mild somatic disease and death occurs typically during the second or third decade of life (Kresse et al. 1978, Klein et al. 1978, Feldhammer et al. 2009, de Ruijter et al. 2011). Edited: Jassal, B, 2012-04-26 Reviewed: Alves, Sandra, 2012-08-27 |
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http://purl.obolibrary.org/obo/HINO_0016265 |
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Reviewed: Coutinho, Maria, 2012-08-27 Authored: Jassal, B, 2012-04-26 Reviewed: Matos, Liliana, 2012-08-27 Mucopolysaccharidosis III (Sanfilippo syndrome) was described in 1963 by a pediatrician named Sylvester Sanfilippo (J. Pediat. 63: 837838, 1963, no reference). Mucopolysaccharidosis type IIIC (MPS IIIC, Sanfilippo syndrome C; MIM:252930) is an autosomal recessive genetic disorder due to the loss of heparan alpha-glucosaminide N-acetyltransferase (HGSNAT; MIM:610453) that normally acetylates the non-reducing terminal alpha-glucosamine residue of heparan sulfate. The molecular defects underlying MPS IIIC remained unknown for almost three decades due to the low tissue content and instability of HGSNAT. But, during the last decade, the gene was cloned in parallel by two different groups and shown to contain 18 exons and span approximately 62Kb (Fan et al. 2006, Hrebicek et al. 2006). Loss of HGSNAT results in build up of this glycosaminglycan (GAG) in cells and tissues and is characterized by severe central nervous system degeneration but only with mild somatic disease and death occurs typically during the second or third decade of life (Kresse et al. 1978, Klein et al. 1978, Feldhammer et al. 2009, de Ruijter et al. 2011). Edited: Jassal, B, 2012-04-26 Reviewed: Alves, Sandra, 2012-08-27 |
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| definition source |
Reactome, http://www.reactome.org Pubmed17033958 Pubmed21235449 Pubmed33384 Pubmed16960811 Pubmed153835 Pubmed19479962 |
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MPS IIIC - Sanfilippo syndrome C |
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HINO:0016265 |
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MPS IIIC - Sanfilippo syndrome C |
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Reactome Database ID Release 432206291 ReactomeREACT_147860 |
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