loading...| Preferred Name | Extrinsic Pathway for Apoptosis | |
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| Definitions |
Known as the "death receptor pathway" the extrinsic or caspase 8/10 dependent pathway is activated by ligand binding. The "death receptors" are specialized cell-surface receptors including Fas/CD95, tumor necrosis factor-alpha (TNF-alpha) receptor 1, and two receptors, DR4 and DR5, that bind to the TNF-alpha related apoptosis-inducing ligand (TRAIL). The extrinsic and intrinsic pathways unite in the activation of Caspase-3, though the two pathways communicate through the pro-apoptotic Bcl-2 family member Bid before uniting at the shared activation of Caspase-3. Authored: Gillespie, ME, 2004-08-10 16:59:18 Reviewed: Vaux, D, 0000-00-00 00:00:00 Edited: Gillespie, ME, 0000-00-00 00:00:00 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0016260 |
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| comment |
Known as the "death receptor pathway" the extrinsic or caspase 8/10 dependent pathway is activated by ligand binding. The "death receptors" are specialized cell-surface receptors including Fas/CD95, tumor necrosis factor-alpha (TNF-alpha) receptor 1, and two receptors, DR4 and DR5, that bind to the TNF-alpha related apoptosis-inducing ligand (TRAIL). The extrinsic and intrinsic pathways unite in the activation of Caspase-3, though the two pathways communicate through the pro-apoptotic Bcl-2 family member Bid before uniting at the shared activation of Caspase-3. Authored: Gillespie, ME, 2004-08-10 16:59:18 Reviewed: Vaux, D, 0000-00-00 00:00:00 Edited: Gillespie, ME, 0000-00-00 00:00:00 |
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| definition source |
Pubmed11048727 Reactome, http://www.reactome.org |
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| label |
Extrinsic Pathway for Apoptosis |
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| prefixIRI |
HINO:0016260 |
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| prefLabel |
Extrinsic Pathway for Apoptosis |
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| seeAlso |
ReactomeREACT_1059 Reactome Database ID Release 43109607 GENE ONTOLOGYGO:0008624 |
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