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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0016073
http://purl.obolibrary.org/obo/HINO_0016073
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|---|---|
| Preferred Name | GRB2 events in EGFR signaling |
| Definitions |
Reviewed: Heldin, CH, 2008-02-12 09:44:02
Autophosphorylated EGFR tyrosine residues are docking sites for many downstream effectors in EGFR signaling. The adaptor protein GRB2 binds to phosphotyrosine residues in the C-tail of EGFR through its SH2 domain. GRB2 is constitutively associated with SOS, a guanine nucleotide exchange factor of RAS. GRB2 binding to phosphorylated EGFR results in the recruitment of SOS to the plasma membrane where it comes in proximity to RAS. This mechanism has been seen to be the model for RAS activation.
Authored: Castagnoli, L, 2006-10-10 13:09:34
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
GRB2 events in EGFR signaling
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| comment |
Reviewed: Heldin, CH, 2008-02-12 09:44:02
Autophosphorylated EGFR tyrosine residues are docking sites for many downstream effectors in EGFR signaling. The adaptor protein GRB2 binds to phosphotyrosine residues in the C-tail of EGFR through its SH2 domain. GRB2 is constitutively associated with SOS, a guanine nucleotide exchange factor of RAS. GRB2 binding to phosphorylated EGFR results in the recruitment of SOS to the plasma membrane where it comes in proximity to RAS. This mechanism has been seen to be the model for RAS activation.
Authored: Castagnoli, L, 2006-10-10 13:09:34
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| prefLabel |
GRB2 events in EGFR signaling
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| located_in | |
| definition source |
Reactome, http://www.reactome.org
Pubmed11498013
Pubmed11706405
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| prefixIRI |
HINO:0016073
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| seeAlso |
ReactomeREACT_12606
Reactome Database ID Release 43179812
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| subClassOf | |
| type | |
| has_part |
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