loading...| Preferred Name | Activation of Chaperone Genes by ATF6-alpha | |
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Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31 Reviewed: Urano, F, 2010-04-30 The N-terminal fragment of ATF6-alpha contains a bZIP domain and binds the sequence CCACG in ER Stress Response Elements (ERSEs). ATF6-alpha binds ERSEs together with the heterotrimeric transcription factor NF-Y, which binds the sequence CCAAT in the ERSEs, and together the two factors activate transcription of ER stress-responsive genes. Evidence from overexpression and knockdowns indicates that ATF6-alpha is a potent activator but its homolog ATF6-beta is not and ATF6-beta may actually reduce expression of ER stress proteins. Authored: May, B, 2009-06-02 00:51:49 Edited: May, B, 2009-06-02 00:51:49 |
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http://purl.obolibrary.org/obo/HINO_0016051 |
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Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31 Reviewed: Urano, F, 2010-04-30 The N-terminal fragment of ATF6-alpha contains a bZIP domain and binds the sequence CCACG in ER Stress Response Elements (ERSEs). ATF6-alpha binds ERSEs together with the heterotrimeric transcription factor NF-Y, which binds the sequence CCAAT in the ERSEs, and together the two factors activate transcription of ER stress-responsive genes. Evidence from overexpression and knockdowns indicates that ATF6-alpha is a potent activator but its homolog ATF6-beta is not and ATF6-beta may actually reduce expression of ER stress proteins. Authored: May, B, 2009-06-02 00:51:49 Edited: May, B, 2009-06-02 00:51:49 |
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| definition source |
Pubmed14973138 Pubmed10866666 Reactome, http://www.reactome.org Pubmed10958673 Pubmed10856300 |
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Activation of Chaperone Genes by ATF6-alpha |
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HINO:0016051 |
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| prefLabel |
Activation of Chaperone Genes by ATF6-alpha |
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| seeAlso |
Reactome Database ID Release 43381183 ReactomeREACT_18423 |
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http://purl.obolibrary.org/obo/HINO_0012731 http://purl.obolibrary.org/obo/HINO_0012733 http://purl.obolibrary.org/obo/HINO_0012735 |