Activation of Chaperone Genes by XBP1(S)

Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31 Reviewed: Urano, F, 2010-04-30 Authored: May, B, 2009-06-02 00:51:49 Edited: May, B, 2009-06-02 00:51:49 Xbp-1 (S) binds the sequence CCACG in ER Stress Responsive Elements (ERSE, consensus sequence CCAAT (N)9 CCACG) located upstream from many genes. The ubiquitous transcription factor NF-Y, a heterotrimer, binds the CCAAT portion of the ERSE and together the IRE1-alpha: NF-Y complex activates transcription of a set of chaperone genes including DNAJB9, EDEM, RAMP4, p58IPK, and others. This results in an increase in protein folding activity in the ER.

http://purl.obolibrary.org/obo/HINO_0016045

Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31

Reviewed: Urano, F, 2010-04-30

Authored: May, B, 2009-06-02 00:51:49

Edited: May, B, 2009-06-02 00:51:49

Xbp-1 (S) binds the sequence CCACG in ER Stress Responsive Elements (ERSE, consensus sequence CCAAT (N)9 CCACG) located upstream from many genes. The ubiquitous transcription factor NF-Y, a heterotrimer, binds the CCAAT portion of the ERSE and together the IRE1-alpha: NF-Y complex activates transcription of a set of chaperone genes including DNAJB9, EDEM, RAMP4, p58IPK, and others. This results in an increase in protein folding activity in the ER.

Pubmed16461360

Reactome, http://www.reactome.org

Pubmed17612490

Pubmed16539657

Pubmed18664523

Pubmed14559994

Activation of Chaperone Genes by XBP1(S)

http://purl.obolibrary.org/obo/NCBITaxon_9606

HINO:0016045

Activation of Chaperone Genes by XBP1(S)

Reactome Database ID Release 43381038

ReactomeREACT_18273

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