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Human Interaction Network Ontology
| Preferred Name | Tolerance of reactive oxygen produced by macrophages | |
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| Definitions |
The expression of <i>AhpC</i> in Mycobacteria does not correlate with virulence; instead, the most important parts of the antioxidant system in <i>Mtb</i> appear to be the lipid cell wall, the enzymes SodB/SodC (superoxide dismutases), and the catalase/peroxidase KatG. Together with the enzyme system that acts on nitrosative stress and the sequestration of iron, these appear to be critical in defending against the macrophage's production of ROS/RNS, and enable the bacterium to exist in the phagosome for extended periods (Zahrt & Deretic 2002). Authored: Stephan, R, 2011-01-10 Reviewed: Warner, D, 2012-04-30 Edited: Jassal, B, 2011-02-28 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0015988 |
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| comment |
The expression of <i>AhpC</i> in Mycobacteria does not correlate with virulence; instead, the most important parts of the antioxidant system in <i>Mtb</i> appear to be the lipid cell wall, the enzymes SodB/SodC (superoxide dismutases), and the catalase/peroxidase KatG. Together with the enzyme system that acts on nitrosative stress and the sequestration of iron, these appear to be critical in defending against the macrophage's production of ROS/RNS, and enable the bacterium to exist in the phagosome for extended periods (Zahrt & Deretic 2002). Authored: Stephan, R, 2011-01-10 Reviewed: Warner, D, 2012-04-30 Edited: Jassal, B, 2011-02-28
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| definition source |
Reactome, http://www.reactome.org Pubmed11970850
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| label |
Tolerance of reactive oxygen produced by macrophages
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| located_in | ||
| prefixIRI |
HINO:0015988
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| prefLabel |
Tolerance of reactive oxygen produced by macrophages
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| seeAlso |
GENE ONTOLOGYGO:0052059 Reactome Database ID Release 431222387 ReactomeREACT_121009
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| subClassOf | ||
| has_part |
http://purl.obolibrary.org/obo/HINO_0004476 http://purl.obolibrary.org/obo/HINO_0004473 http://purl.obolibrary.org/obo/HINO_0004474 http://purl.obolibrary.org/obo/HINO_0004470 http://purl.obolibrary.org/obo/HINO_0004472 |
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