Authored: Stephan, R, 2011-01-10 Reviewed: Warner, D, 2012-04-30 Reactive nitrogen species (RNS), like reactive oxygen species, have numerous target molecules in the bacterial cell, and <i>Mtb</i> has developed remedies to the most important ones of them. This is a key reason for its ability to stay alive in the hostile environment of the late phagosome within human macrophages.<br><i>Mtb</i> repairs single-base DNA damage caused by DNA alkylation; it scavenges nitric oxide with large amounts of mycothiol and methionine-rich proteins (the nitroso compounds later being reduced). Nitric oxide and peroxynitrite are also directly reduced by a battery of hemoglobins and peroxiredoxins, supported by a network of thioredoxins and respective NADPH-dependent reductases (Fang. 2004). Edited: Jassal, B, 2011-02-28

http://purl.obolibrary.org/obo/HINO_0015987

Authored: Stephan, R, 2011-01-10

Reviewed: Warner, D, 2012-04-30

Reactive nitrogen species (RNS), like reactive oxygen species, have numerous target molecules in the bacterial cell, and Mtb has developed remedies to the most important ones of them. This is a key reason for its ability to stay alive in the hostile environment of the late phagosome within human macrophages.
Mtb repairs single-base DNA damage caused by DNA alkylation; it scavenges nitric oxide with large amounts of mycothiol and methionine-rich proteins (the nitroso compounds later being reduced). Nitric oxide and peroxynitrite are also directly reduced by a battery of hemoglobins and peroxiredoxins, supported by a network of thioredoxins and respective NADPH-dependent reductases (Fang. 2004).

Edited: Jassal, B, 2011-02-28

Reactome, http://www.reactome.org

Pubmed15378046

Tolerance by Mtb to nitric oxide produced by macrophages

http://purl.obolibrary.org/obo/NCBITaxon_1773

HINO:0015987

Tolerance by Mtb to nitric oxide produced by macrophages

ReactomeREACT_120983

Reactome Database ID Release 431222538

GENE ONTOLOGYGO:0052060

http://purl.obolibrary.org/obo/INO_0000021

http://purl.obolibrary.org/obo/HINO_0004471

http://purl.obolibrary.org/obo/HINO_0004404

http://purl.obolibrary.org/obo/HINO_0004408

http://purl.obolibrary.org/obo/HINO_0004406

http://purl.obolibrary.org/obo/HINO_0004402

http://purl.obolibrary.org/obo/HINO_0004469

http://purl.obolibrary.org/obo/HINO_0004467

http://purl.obolibrary.org/obo/HINO_0004466

http://purl.obolibrary.org/obo/HINO_0004468