loading...| Preferred Name | Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter | |
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Authored: Comai, L, 2003-07-03 17:13:29 Human SL1 does not bind to DNA itself, rather it is recruited to the rDNA promoter through a physical interaction with UBF-1. Phosphorylation of UBF-1 within the carboxy-terminal region is required for SL1 binding. SL1 consists of TATA-binding protein (TBP) and three associated factors (TAFIs). SL1 has no sequence-specific DNA binding activity its recruitment to the promoter being mediated by specific interactions with UBF. Once bound the SL1 complex makes direct contact with the DNA promoter and guides promoter-specific initiation. <p>Studies to identify the mechanistic relationship between SL1 and UBF-1 have indicated that the interaction between UBF-1 and SL1 is regulated by tumor suppressor proteins such as Rb and P53, although it has also been proposed that Rb prevents UBF-1 from binding to DNA itself. Edited: Gillespie, ME, 0000-00-00 00:00:00 |
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http://purl.obolibrary.org/obo/HINO_0015824 |
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Authored: Comai, L, 2003-07-03 17:13:29 Human SL1 does not bind to DNA itself, rather it is recruited to the rDNA promoter through a physical interaction with UBF-1. Phosphorylation of UBF-1 within the carboxy-terminal region is required for SL1 binding. SL1 consists of TATA-binding protein (TBP) and three associated factors (TAFIs). SL1 has no sequence-specific DNA binding activity its recruitment to the promoter being mediated by specific interactions with UBF. Once bound the SL1 complex makes direct contact with the DNA promoter and guides promoter-specific initiation. Studies to identify the mechanistic relationship between SL1 and UBF-1 have indicated that the interaction between UBF-1 and SL1 is regulated by tumor suppressor proteins such as Rb and P53, although it has also been proposed that Rb prevents UBF-1 from binding to DNA itself. Edited: Gillespie, ME, 0000-00-00 00:00:00 |
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Pubmed10913176 Reactome, http://www.reactome.org Pubmed11486020 Pubmed7491500 Pubmed11042686 Pubmed10082553 |
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Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter |
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HINO:0015824 |
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Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter |
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ReactomeREACT_105 Reactome Database ID Release 4373739 |
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