Human Interaction Network Ontology

Last uploaded: June 27, 2014
Id http://purl.obolibrary.org/obo/HINO_0015794
http://purl.obolibrary.org/obo/HINO_0015794
Preferred Name

RNA Polymerase III Promoter Opening at Type 1 Promoters

Definitions
Authored: Geiduschek, E, 2004-03-29 17:50:49 Pol III initiation complexes open the promoter spontaneously. Indeed, this is the general case for DNA-dependent RNA polymerases. Only pol II, with its requirement for TFIIH-directed and ATP-dependent promoter opening is exceptional. TFIIH introduces a layer of mechanism that is not in the repertoire of any other transcriptase. Thus, it is pol III-mediated transcription that is, from a mechanistic perspective, most directly comparable with archaeal and also bacterial transcription. <p>As promoter opening has been analyzed only in the S. cerevisiae this event is Inferred from the homologous pathway in yeast. Edited: Gillespie, ME, 0000-00-00 00:00:00
Type http://www.w3.org/2002/07/owl#Class
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