Human Interaction Network Ontology

Last uploaded: June 27, 2014
Preferred Name

RNA Polymerase III Promoter Opening at Type 2 Promoters
Synonyms
Definitions

Authored: Geiduschek, E, 2004-03-29 17:50:49 Pol III initiation complexes open the promoter spontaneously. Indeed, this is the general case for DNA-dependent RNA polymerases. Only pol II, with its requirement for TFIIH-directed and ATP-dependent promoter opening is exceptional. TFIIH introduces a layer of mechanism that is not in the repertoire of any other transcriptase. Thus, it is pol III-mediated transcription that is, from a mechanistic perspective, most directly comparable with archaeal and also bacterial transcription. <p>As promoter opening has been analyzed only in the S. cerevisiae this event is Inferred from the homologous pathway in yeast. Edited: Gillespie, ME, 0000-00-00 00:00:00

ID

http://purl.obolibrary.org/obo/HINO_0015790

comment

Authored: Geiduschek, E, 2004-03-29 17:50:49

Pol III initiation complexes open the promoter spontaneously. Indeed, this is the general case for DNA-dependent RNA polymerases. Only pol II, with its requirement for TFIIH-directed and ATP-dependent promoter opening is exceptional. TFIIH introduces a layer of mechanism that is not in the repertoire of any other transcriptase. Thus, it is pol III-mediated transcription that is, from a mechanistic perspective, most directly comparable with archaeal and also bacterial transcription.

As promoter opening has been analyzed only in the S. cerevisiae this event is Inferred from the homologous pathway in yeast.

Edited: Gillespie, ME, 0000-00-00 00:00:00

definition source

Reactome, http://www.reactome.org

has input

http://purl.obolibrary.org/obo/HINO_0012643

has output

http://purl.obolibrary.org/obo/HINO_0012610

label

RNA Polymerase III Promoter Opening at Type 2 Promoters

prefixIRI

HINO:0015790

prefLabel

RNA Polymerase III Promoter Opening at Type 2 Promoters

seeAlso

ReactomeREACT_793

Reactome Database ID Release 43112150

subClassOf

http://purl.obolibrary.org/obo/INO_0000040

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