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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0015680
http://purl.obolibrary.org/obo/HINO_0015680
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|---|---|
| Preferred Name | APOBEC3G mediated resistance to HIV-1 infection |
| Definitions |
Edited: Matthews, L, 2007-01-30 11:27:41
Reviewed: Mulder, L, 2007-01-30 22:57:00
Reviewed: Simon, V, 2007-01-30 23:07:12
Representatives of the apolipoprotein B mRNA editing enzyme catalytic polypeptide 3 (APOBEC3) family provide innate resistance to exogeneous and endogenous retroviruses (see Cullen 2006 for a recent review). Humans and other primates encode a cluster of seven different cytidine deaminases with APOBEC3G, APOBEC3F and APOBEC3B having some anti HIV-1 activity. Our understanding is most complete for APOBEC3G which has been described first and the reactions described herein will focus on this representative enzyme.<br><br>APOBEC3G is a cytoplasmic protein which strongly restricts replication of Vif deficient HIV-1 (Sheehy 2002). It is expressed in cell populations that are susceptible to HIV infection (e.g., T-lymphocytes and macrophages). In the producer cell, APOBEC3G is incorporated into budding HIV-1 particles through an interaction with HIV-1 gag nucleocapsid (NC) protein in a RNA-dependent fashion. <br><br>Within the newly infected cell (= target cell), virus-associated APOBEC3G regulates the infectivity of HIV-1 by deaminating cytidine to uracil in the minus-strand viral DNA intermediate during reverse transcription. Deamination results in the induction of G-to-A hypermutations in the plus-strand viral DNA which subsequently can either be integrated as a non-functional provirus or degraded before integration.
Authored: Matthews, L, 2006-06-07 20:09:24
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
APOBEC3G mediated resistance to HIV-1 infection
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| comment |
Edited: Matthews, L, 2007-01-30 11:27:41
Reviewed: Mulder, L, 2007-01-30 22:57:00
Reviewed: Simon, V, 2007-01-30 23:07:12
Representatives of the apolipoprotein B mRNA editing enzyme catalytic polypeptide 3 (APOBEC3) family provide innate resistance to exogeneous and endogenous retroviruses (see Cullen 2006 for a recent review). Humans and other primates encode a cluster of seven different cytidine deaminases with APOBEC3G, APOBEC3F and APOBEC3B having some anti HIV-1 activity. Our understanding is most complete for APOBEC3G which has been described first and the reactions described herein will focus on this representative enzyme.<br><br>APOBEC3G is a cytoplasmic protein which strongly restricts replication of Vif deficient HIV-1 (Sheehy 2002). It is expressed in cell populations that are susceptible to HIV infection (e.g., T-lymphocytes and macrophages). In the producer cell, APOBEC3G is incorporated into budding HIV-1 particles through an interaction with HIV-1 gag nucleocapsid (NC) protein in a RNA-dependent fashion. <br><br>Within the newly infected cell (= target cell), virus-associated APOBEC3G regulates the infectivity of HIV-1 by deaminating cytidine to uracil in the minus-strand viral DNA intermediate during reverse transcription. Deamination results in the induction of G-to-A hypermutations in the plus-strand viral DNA which subsequently can either be integrated as a non-functional provirus or degraded before integration.
Authored: Matthews, L, 2006-06-07 20:09:24
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| prefLabel |
APOBEC3G mediated resistance to HIV-1 infection
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| located_in | |
| definition source |
Pubmed16414984
Reactome, http://www.reactome.org
Pubmed15152192
Pubmed15098018
Pubmed12167863
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| prefixIRI |
HINO:0015680
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| seeAlso |
ReactomeREACT_9406
Reactome Database ID Release 43180689
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| subClassOf | |
| type | |
| has_part |
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