Human Interaction Network Ontology

Last uploaded: June 27, 2014
Preferred Name

Phosphorylation of BRF1 by MK2
Synonyms
Definitions

MAPK-activated protein kinase 2 (MK2) phosphorylates BRF1 at serine 54, serine 92, serine 203, and an unknown site in the C terminus. Phosphorylation inhibits the ability of BRF1 to cause degradation of RNA. It is unknown if tetraphosphorylated BRF1 binds 14-3-3 in the same way as diphosphorylated BRF1 does. has a Stoichiometric coefficient of 3 Reviewed: Wilusz, J, 2010-06-29 Authored: May, B, 2009-12-29 Edited: May, B, 2009-12-29

ID

http://purl.obolibrary.org/obo/HINO_0015639

comment

MAPK-activated protein kinase 2 (MK2) phosphorylates BRF1 at serine 54, serine 92, serine 203, and an unknown site in the C terminus. Phosphorylation inhibits the ability of BRF1 to cause degradation of RNA. It is unknown if tetraphosphorylated BRF1 binds 14-3-3 in the same way as diphosphorylated BRF1 does.

has a Stoichiometric coefficient of 3

Reviewed: Wilusz, J, 2010-06-29

Authored: May, B, 2009-12-29

Edited: May, B, 2009-12-29

definition source

Pubmed18326031

Reactome, http://www.reactome.org

has input

http://purl.obolibrary.org/obo/HINO_0013353

http://purl.obolibrary.org/obo/CHEBI_15422

has output

http://purl.obolibrary.org/obo/HINO_0013311

http://purl.obolibrary.org/obo/CHEBI_16761

label

Phosphorylation of BRF1 by MK2

prefixIRI

HINO:0015639

prefLabel

Phosphorylation of BRF1 by MK2

seeAlso

Reactome Database ID Release 43450474

ReactomeREACT_25285

EC Number: 2.7.11

subClassOf

http://purl.obolibrary.org/obo/INO_0000040

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