loading...| Preferred Name | Glycogen breakdown (glycogenolysis) | |
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| Definitions |
Glycogen breakdown occurs via the same chemical steps in all tissues but is separately regulated via tissue specific isozymes and signaling pathways that enable distinct physiological fates for liver glycogen and that in other tissues. Glycogen phosphorylase, which can be activated by phosphorylase kinase, catalyzes the removal of glucose residues as glucose 1-phosphate from the ends of glycogen branches. The final four residues of each branch are removed in two steps catalyzed by debranching enzyme, and further glycogen phosphorylase activity completes the process of glycogen breakdown. The figure shows the actions of phosphorylase and debranching enzyme. The first glucose residue in each branch is released as free glucose; all other residues are released as glucose 1-phosphate. The latter molecule can be converted to glucose 6-phosphate in a step shared with other pathways (Villar-Palasi and Larner 1970; Hers 1976). Authored: 2003-02-15 00:00:00 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0015629 |
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| comment |
Glycogen breakdown occurs via the same chemical steps in all tissues but is separately regulated via tissue specific isozymes and signaling pathways that enable distinct physiological fates for liver glycogen and that in other tissues. Glycogen phosphorylase, which can be activated by phosphorylase kinase, catalyzes the removal of glucose residues as glucose 1-phosphate from the ends of glycogen branches. The final four residues of each branch are removed in two steps catalyzed by debranching enzyme, and further glycogen phosphorylase activity completes the process of glycogen breakdown. The figure shows the actions of phosphorylase and debranching enzyme. The first glucose residue in each branch is released as free glucose; all other residues are released as glucose 1-phosphate. The latter molecule can be converted to glucose 6-phosphate in a step shared with other pathways (Villar-Palasi and Larner 1970; Hers 1976). Authored: 2003-02-15 00:00:00 |
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| definition source |
Pubmed183599 Pubmed4320262 Reactome, http://www.reactome.org |
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| label |
Glycogen breakdown (glycogenolysis) |
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| prefixIRI |
HINO:0015629 |
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| prefLabel |
Glycogen breakdown (glycogenolysis) |
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| seeAlso |
Reactome Database ID Release 4370221 GENE ONTOLOGYGO:0005980 ReactomeREACT_1008 |
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| has_part |
http://purl.obolibrary.org/obo/HINO_0019111 http://purl.obolibrary.org/obo/HINO_0019109 http://purl.obolibrary.org/obo/HINO_0019045 http://purl.obolibrary.org/obo/HINO_0019047 http://purl.obolibrary.org/obo/HINO_0019067 http://purl.obolibrary.org/obo/HINO_0019065 http://purl.obolibrary.org/obo/HINO_0019071 http://purl.obolibrary.org/obo/HINO_0019074 http://purl.obolibrary.org/obo/HINO_0019077 http://purl.obolibrary.org/obo/HINO_0019080 http://purl.obolibrary.org/obo/HINO_0019085 http://purl.obolibrary.org/obo/HINO_0019089 |