loading...| Preferred Name | Peptide chain elongation | |
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| Definitions |
The mechanism of a peptide bond requires the movement of three protons. First the deprotonation of the ammonium ion generates a reactive amine, allowing a nucleophilic attack on the carbonyl group. This is followed by the loss of a proton from the reaction intermediate, only to be taken up by the oxygen on the leaving group (from the end of the amino acid chain bound to the tRNA in the P-site). The peptide bond formation results in the net loss of one water molecule, leaving a deacylated-tRNA in the P-site, and a nascent polypeptide chain one amino acid larger in the A-site.<br>For the purpose of illustration, the figures used in the section show one amino acid being added to a peptidyl-tRNA with a growing peptide chain.<br> Authored: Gopinathrao, G, 2005-03-13 01:37:39 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0015396 |
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| comment |
The mechanism of a peptide bond requires the movement of three protons. First the deprotonation of the ammonium ion generates a reactive amine, allowing a nucleophilic attack on the carbonyl group. This is followed by the loss of a proton from the reaction intermediate, only to be taken up by the oxygen on the leaving group (from the end of the amino acid chain bound to the tRNA in the P-site). The peptide bond formation results in the net loss of one water molecule, leaving a deacylated-tRNA in the P-site, and a nascent polypeptide chain one amino acid larger in the A-site. Authored: Gopinathrao, G, 2005-03-13 01:37:39 |
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| definition source |
Reactome, http://www.reactome.org Pubmed12297040 |
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| label |
Peptide chain elongation |
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| located_in | ||
| prefixIRI |
HINO:0015396 |
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| prefLabel |
Peptide chain elongation |
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| seeAlso |
Reactome Database ID Release 43156902 ReactomeREACT_1404 |
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| subClassOf | ||
| has_part |
http://purl.obolibrary.org/obo/HINO_0014835 http://purl.obolibrary.org/obo/HINO_0014831 http://purl.obolibrary.org/obo/HINO_0014832 |