loading...| Preferred Name | Glycolysis | |
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| Definitions |
The reactions of glycolysis (e.g., van Wijk and van Solinge 2005) convert glucose 6-phosphate to pyruvate. The entire process is cytosolic. Glucose 6-phosphate is reversibly isomerized to form fructose 6-phosphate. Phosphofructokinase 1 catalyzes the physiologically irreversible phosphorylation of fructose 6-phosphate to form fructose 1,6-bisphosphate. In six reversible reactions, fructose 1,6-bisphosphate is converted to two molecules of phosphoenolpyruvate and two molecules of NAD+ are reduced to NADH + H+. Each molecule of phosphoenolpyruvate reacts with ADP to form ATP and pyruvate in a physiologically irreversible reaction. Under aerobic conditions the NADH +H+ can be reoxidized to NAD+ via electron transport to yield additional ATP, while under anaerobic conditions or in cells lacking mitochondria NAD+ can be regenerated via the reduction of pyruvate to lactate. Authored: Schmidt, EE, 2003-01-28 00:00:00 |
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http://purl.obolibrary.org/obo/HINO_0015271 |
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| comment |
The reactions of glycolysis (e.g., van Wijk and van Solinge 2005) convert glucose 6-phosphate to pyruvate. The entire process is cytosolic. Glucose 6-phosphate is reversibly isomerized to form fructose 6-phosphate. Phosphofructokinase 1 catalyzes the physiologically irreversible phosphorylation of fructose 6-phosphate to form fructose 1,6-bisphosphate. In six reversible reactions, fructose 1,6-bisphosphate is converted to two molecules of phosphoenolpyruvate and two molecules of NAD+ are reduced to NADH + H+. Each molecule of phosphoenolpyruvate reacts with ADP to form ATP and pyruvate in a physiologically irreversible reaction. Under aerobic conditions the NADH +H+ can be reoxidized to NAD+ via electron transport to yield additional ATP, while under anaerobic conditions or in cells lacking mitochondria NAD+ can be regenerated via the reduction of pyruvate to lactate. Authored: Schmidt, EE, 2003-01-28 00:00:00 |
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| definition source |
Pubmed16051738 Reactome, http://www.reactome.org |
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| label |
Glycolysis |
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| prefixIRI |
HINO:0015271 |
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| prefLabel |
Glycolysis |
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| seeAlso |
GENE ONTOLOGYGO:0006096 ReactomeREACT_1383 Reactome Database ID Release 4370171 |
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http://purl.obolibrary.org/obo/HINO_0019658 http://purl.obolibrary.org/obo/HINO_0019655 http://purl.obolibrary.org/obo/HINO_0019653 http://purl.obolibrary.org/obo/HINO_0019652 http://purl.obolibrary.org/obo/HINO_0019657 http://purl.obolibrary.org/obo/HINO_0019659 http://purl.obolibrary.org/obo/HINO_0019621 http://purl.obolibrary.org/obo/HINO_0019619 http://purl.obolibrary.org/obo/HINO_0019663 |