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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | Binding of Lsm1-7 Complex to Deadenylated mRNA | |
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| Definitions |
Edited: May, B, 2009-07-22 Reviewed: Wilusz, J, 2009-09-17 Authored: May, B, 2009-07-22 The Lsm1-7 complex forms a heptameric ring that binds the 3' oligoadenylated ends of mRNAs that have been deadenylated. The bound Lsm1-7 may prevent access of the exosome (a 3' to 5' exonuclease) to the 3' end and thereby direct the mRNA to the 5' to 3' exonuclease pathway. The yeast Lsm1-7 complex has a preference for oligoadenylated RNA compared to polyadenylated RNA, however other determinants of binding by Lsm1-7 are unknown. |
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| ID |
http://purl.obolibrary.org/obo/HINO_0015261 |
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| comment |
Edited: May, B, 2009-07-22 Reviewed: Wilusz, J, 2009-09-17 Authored: May, B, 2009-07-22 The Lsm1-7 complex forms a heptameric ring that binds the 3' oligoadenylated ends of mRNAs that have been deadenylated. The bound Lsm1-7 may prevent access of the exosome (a 3' to 5' exonuclease) to the 3' end and thereby direct the mRNA to the 5' to 3' exonuclease pathway. The yeast Lsm1-7 complex has a preference for oligoadenylated RNA compared to polyadenylated RNA, however other determinants of binding by Lsm1-7 are unknown.
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| definition source |
Pubmed19279404 Pubmed11283721 Pubmed15475613 Pubmed16141059 Pubmed15231747 Reactome, http://www.reactome.org Pubmed16051491 Pubmed14749774 Pubmed17245413 Pubmed19239894 Pubmed15711010
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| label |
Binding of Lsm1-7 Complex to Deadenylated mRNA
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| prefixIRI |
HINO:0015261
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| prefLabel |
Binding of Lsm1-7 Complex to Deadenylated mRNA
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| seeAlso |
ReactomeREACT_20540 Reactome Database ID Release 43429978
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