loading...| Preferred Name | Deadenylation of mRNA by the CCR4-NOT Complex | |
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| Definitions |
The CCR4-NOT complex hydrolyzes adenosine residues at the 3' end of polyadenylated mRNA, shortening the number of adenosine residues to about 10-15 residues and yielding adenosine 5'-monophosphate. CNOT6 and CNOT6L are the exoribonucleases responsible for hydrolysis. Activity of the CCR4-NOT complex is inhibited by PABP bound to the poly(A) tail of the mRNA. The trigger for activation of deadenylation by the CCR4-NOT complex is unknown. Complexes containing CNOT7 rather than CNOT8 appear to be responsible for cytoplasmic mRNA decay. Edited: May, B, 2009-07-22 Reviewed: Wilusz, J, 2009-09-17 Authored: May, B, 2009-07-22 |
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http://purl.obolibrary.org/obo/HINO_0015259 |
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| comment |
The CCR4-NOT complex hydrolyzes adenosine residues at the 3' end of polyadenylated mRNA, shortening the number of adenosine residues to about 10-15 residues and yielding adenosine 5'-monophosphate. CNOT6 and CNOT6L are the exoribonucleases responsible for hydrolysis. Activity of the CCR4-NOT complex is inhibited by PABP bound to the poly(A) tail of the mRNA. The trigger for activation of deadenylation by the CCR4-NOT complex is unknown. Complexes containing CNOT7 rather than CNOT8 appear to be responsible for cytoplasmic mRNA decay. Edited: May, B, 2009-07-22 Reviewed: Wilusz, J, 2009-09-17 Authored: May, B, 2009-07-22 |
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| definition source |
Pubmed11283721 Pubmed15475613 Pubmed11889047 Pubmed19558367 Pubmed16141059 Reactome, http://www.reactome.org Pubmed10637334 Pubmed16284618 Pubmed14749774 Pubmed17245413 Pubmed19239894 Pubmed18625844 |
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http://purl.obolibrary.org/obo/UniProt_P23588 http://purl.obolibrary.org/obo/UniProt_Q04637 http://purl.obolibrary.org/obo/HINO_0014234 http://purl.obolibrary.org/obo/UniProt_P11940 http://purl.obolibrary.org/obo/UniProt_P06730 http://purl.obolibrary.org/obo/HINO_0018502 |
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| label |
Deadenylation of mRNA by the CCR4-NOT Complex |
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| prefixIRI |
HINO:0015259 |
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| prefLabel |
Deadenylation of mRNA by the CCR4-NOT Complex |
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| seeAlso |
Reactome Database ID Release 43429955 EC Number: 3.1.13.4 ReactomeREACT_20651 |
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