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Human Interaction Network Ontology
| Preferred Name | Deadenylation of mRNA by PARN | |
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| Definitions |
Edited: May, B, 2009-07-22 Reviewed: Wilusz, J, 2009-09-17 Authored: May, B, 2009-07-22 The PARN exoribonuclease hydrolyzes adenosine residues at the 3' ends of polyadenylated mRNA, shortening the poly(A) tail from about 80 adenosine residues to about 10-15 residues and yielding adenosine 5'-monophosphate. PARN interacts simultaneously with the poly(A) tail and with the 7-methylguanosine cap of the mRNA, therefore it is believed that PARN displaces the eIF4F cap-binding complex. The trigger for deadenylation by PARN is unknown. PARN is also part of a complex that regulates poly(A) tail length and hence translation in developing oocytes. |
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http://purl.obolibrary.org/obo/HINO_0015254 |
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Edited: May, B, 2009-07-22 Reviewed: Wilusz, J, 2009-09-17 Authored: May, B, 2009-07-22 The PARN exoribonuclease hydrolyzes adenosine residues at the 3' ends of polyadenylated mRNA, shortening the poly(A) tail from about 80 adenosine residues to about 10-15 residues and yielding adenosine 5'-monophosphate. PARN interacts simultaneously with the poly(A) tail and with the 7-methylguanosine cap of the mRNA, therefore it is believed that PARN displaces the eIF4F cap-binding complex. The trigger for deadenylation by PARN is unknown. PARN is also part of a complex that regulates poly(A) tail length and hence translation in developing oocytes.
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| definition source |
Pubmed11283721 Pubmed15475613 Pubmed16141059 Reactome, http://www.reactome.org Pubmed9099687 Pubmed17052452 Pubmed14749774 Pubmed1355481 Pubmed10882133 Pubmed17245413 Pubmed19239894
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http://purl.obolibrary.org/obo/UniProt_P23588 http://purl.obolibrary.org/obo/UniProt_Q04637 http://purl.obolibrary.org/obo/HINO_0014234 http://purl.obolibrary.org/obo/UniProt_P11940 http://purl.obolibrary.org/obo/UniProt_P06730 http://purl.obolibrary.org/obo/HINO_0018502 |
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Deadenylation of mRNA by PARN
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HINO:0015254
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Deadenylation of mRNA by PARN
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| seeAlso |
ReactomeREACT_20662 EC Number: 3.1.13.4 Reactome Database ID Release 43429992
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