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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | CDT1 association with the CDC6:ORC:origin complex | |
| Synonyms |
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| Definitions |
Initiation protein Cdt1 was first identified in X. laevis, where it has been shown to be the second component of licensing factor (RLF-B) and in S. pombe. Cdt1 homologs have been identified in D. melanogaster, humans, and S. cerevisiae. Genetic studies in S. pombe have shown that binding of Cdc6 to chromatin requires the prior binding of Cdc18, the S. pombe homolog of Cdc6. In humans, the function of CDT1 is regulated during the cell cycle by its tight association with an inhibitory factor, geminin. |
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| ID |
http://purl.obolibrary.org/obo/HINO_0015232 |
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| comment |
Initiation protein Cdt1 was first identified in X. laevis, where it has been shown to be the second component of licensing factor (RLF-B) and in S. pombe. Cdt1 homologs have been identified in D. melanogaster, humans, and S. cerevisiae. Genetic studies in S. pombe have shown that binding of Cdc6 to chromatin requires the prior binding of Cdc18, the S. pombe homolog of Cdc6. In humans, the function of CDT1 is regulated during the cell cycle by its tight association with an inhibitory factor, geminin.
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| definition source |
Pubmed11836525 Pubmed9635433 Pubmed11125146 Reactome, http://www.reactome.org Pubmed11175741 Pubmed10898791 Pubmed10766247 Pubmed9442876 Pubmed10766248
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| label |
CDT1 association with the CDC6:ORC:origin complex
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| located_in | ||
| prefixIRI |
HINO:0015232
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| prefLabel |
CDT1 association with the CDC6:ORC:origin complex
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| seeAlso |
ReactomeREACT_1949 Reactome Database ID Release 4368827
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| subClassOf | ||
| has_part |
http://purl.obolibrary.org/obo/HINO_0014852 |
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