loading...| Preferred Name | Prostacyclin signalling through prostacyclin receptor | |
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| Definitions |
Prostacyclin (PGI2) is continuously produced by healthy vascular endothelial cells. It inhibits platelet activation through interaction with the Gs-coupled receptor PTGIR, leading to increased cAMP, a consequent increase in cAMP-dependent protein kinase activity which prevents increases of cytoplasmic [Ca2+] necessary for activation (Woulfe et al. 2001). PGI2 is also an effective vasodilator. These effects oppose the effects of thromboxane (TXA2), another eicosanoid, creating a balance of blood circulation and platelet activation. Authored: Akkerman, JW, 2009-06-03 Edited: Jupe, S, 2010-06-07 Reviewed: Kunapuli, SP, 2010-06-07 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0015220 |
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| comment |
Prostacyclin (PGI2) is continuously produced by healthy vascular endothelial cells. It inhibits platelet activation through interaction with the Gs-coupled receptor PTGIR, leading to increased cAMP, a consequent increase in cAMP-dependent protein kinase activity which prevents increases of cytoplasmic [Ca2+] necessary for activation (Woulfe et al. 2001). PGI2 is also an effective vasodilator. These effects oppose the effects of thromboxane (TXA2), another eicosanoid, creating a balance of blood circulation and platelet activation. Authored: Akkerman, JW, 2009-06-03 Edited: Jupe, S, 2010-06-07 Reviewed: Kunapuli, SP, 2010-06-07 |
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| definition source |
Pubmed11413156 Reactome, http://www.reactome.org Pubmed17164137 |
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| label |
Prostacyclin signalling through prostacyclin receptor |
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| prefixIRI |
HINO:0015220 |
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| prefLabel |
Prostacyclin signalling through prostacyclin receptor |
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| seeAlso |
Reactome Database ID Release 43392851 ReactomeREACT_23946 |
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| has_part |
http://purl.obolibrary.org/obo/HINO_0014546 http://purl.obolibrary.org/obo/HINO_0014544 |