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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin | |
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| Definitions |
After pre-RC assembly and Cdc45 association with the origin of replication, Replication Protein A (RPA) also associates with chromatin. RPA is a heterotrimeric complex containing p70, p34, and p11 subunits, and also is required for DNA recombination and DNA repair. The p70 subunit of RPA binds to the primase subunits of Pol alpha:primase. The p70 and p34 subunits of RPA are phosphorylated in a cell cycle-dependent manner. RPA is a single-strand DNA (ssDNA) binding protein and its association with chromatin at this stage suggests that DNA is partially unwound. This suggestion has been confirmed by detection of ssDNA in budding yeast origins of replication using chemical methods. |
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| ID |
http://purl.obolibrary.org/obo/HINO_0014867 |
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| comment |
After pre-RC assembly and Cdc45 association with the origin of replication, Replication Protein A (RPA) also associates with chromatin. RPA is a heterotrimeric complex containing p70, p34, and p11 subunits, and also is required for DNA recombination and DNA repair. The p70 subunit of RPA binds to the primase subunits of Pol alpha:primase. The p70 and p34 subunits of RPA are phosphorylated in a cell cycle-dependent manner. RPA is a single-strand DNA (ssDNA) binding protein and its association with chromatin at this stage suggests that DNA is partially unwound. This suggestion has been confirmed by detection of ssDNA in budding yeast origins of replication using chemical methods.
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| definition source |
Pubmed1311258 Pubmed2200738 Pubmed10757793 Pubmed9242902 Reactome, http://www.reactome.org Pubmed10882098 Pubmed10473346
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DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin
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| prefixIRI |
HINO:0014867
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DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin
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| seeAlso |
ReactomeREACT_789 Reactome Database ID Release 4368916
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