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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | DNA polymerase alpha:primase binds at the origin | |
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| Definitions |
DNA polymerase alpha:primase is comprised of four subunits, p180, p70, p58, and p49. The two primase subunits, p58 and p49, form a tight complex. The p49 subunit contains the DNA primase activity and one role of p58 appears to be tethering p49 to p180, the DNA polymerase catalytic subunit. The fourth subunit, p70, binds p180 and may tether the DNA polymerase alpha:primase complex to Cdc45. |
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| ID |
http://purl.obolibrary.org/obo/HINO_0014866 |
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| comment |
DNA polymerase alpha:primase is comprised of four subunits, p180, p70, p58, and p49. The two primase subunits, p58 and p49, form a tight complex. The p49 subunit contains the DNA primase activity and one role of p58 appears to be tethering p49 to p180, the DNA polymerase catalytic subunit. The fourth subunit, p70, binds p180 and may tether the DNA polymerase alpha:primase complex to Cdc45.
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| definition source |
Pubmed10757793 Reactome, http://www.reactome.org Pubmed12045100 Pubmed10882098 Pubmed11395402 Pubmed8253737
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| label |
DNA polymerase alpha:primase binds at the origin
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| prefixIRI |
HINO:0014866
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| prefLabel |
DNA polymerase alpha:primase binds at the origin
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| seeAlso |
Reactome Database ID Release 4368914 ReactomeREACT_929
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