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Human Interaction Network Ontology
| Preferred Name | Loading and methylation of Sm proteins onto SMN Complexes | |
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| Definitions |
Reviewed: Luhrmann, R, 2007-04-30 18:31:22 Authored: Gillespie, ME, 2007-01-29 20:29:54 The survival of motor neurons (SMN) complex binds to Sm proteins and small nuclear RNAs (snRNAs) in the cytoplasm. Sm is part the SMN multiprotein complex that contains Gemins 2 â 7, including the DEAD-box RNA helicase Gemin3. The binding of the SMN complex to the snRNAs depends on the presence of specific, high-affinity (nanomolar) binding domains in the snRNAs. The SMN complex binds the Sm proteins through the Sm domains interaction with the Gemins, the TUDOR domain, and through unique arginine- and glycine-rich (RG) domains found in three of these, SmB, SmD1 and SmD3. The association with RG domains is strongly enhanced by the post-translational symmetric dimethylation of specific arginines in these domains, a process that is carried out by the methylosome (JBP1 or PRMT5) complex. |
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http://purl.obolibrary.org/obo/HINO_0014841 |
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| comment |
Reviewed: Luhrmann, R, 2007-04-30 18:31:22 Authored: Gillespie, ME, 2007-01-29 20:29:54 The survival of motor neurons (SMN) complex binds to Sm proteins and small nuclear RNAs (snRNAs) in the cytoplasm. Sm is part the SMN multiprotein complex that contains Gemins 2 â 7, including the DEAD-box RNA helicase Gemin3. The binding of the SMN complex to the snRNAs depends on the presence of specific, high-affinity (nanomolar) binding domains in the snRNAs. The SMN complex binds the Sm proteins through the Sm domains interaction with the Gemins, the TUDOR domain, and through unique arginine- and glycine-rich (RG) domains found in three of these, SmB, SmD1 and SmD3. The association with RG domains is strongly enhanced by the post-translational symmetric dimethylation of specific arginines in these domains, a process that is carried out by the methylosome (JBP1 or PRMT5) complex.
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| definition source |
Pubmed11714716 Pubmed10747894 Pubmed10601333 Reactome, http://www.reactome.org Pubmed11720283 Pubmed10725331 Pubmed12065586 Pubmed9323129 Pubmed9323130 Pubmed11715014 Pubmed10851237 Pubmed11748230
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http://purl.obolibrary.org/obo/UniProt_P62318 http://purl.obolibrary.org/obo/UniProt_P62314 http://purl.obolibrary.org/obo/UniProt_P62316 http://purl.obolibrary.org/obo/UniProt_P62306 http://purl.obolibrary.org/obo/UniProt_P62308 http://purl.obolibrary.org/obo/UniProt_P62304 http://purl.obolibrary.org/obo/HINO_0013897 |
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Loading and methylation of Sm proteins onto SMN Complexes
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| prefixIRI |
HINO:0014841
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Loading and methylation of Sm proteins onto SMN Complexes
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| seeAlso |
Reactome Database ID Release 43191790 GENE ONTOLOGYGO:0000387 ReactomeREACT_10041
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