Link to this page
Human Interaction Network Ontology
| Preferred Name | Translocation of ribosome by 3 bases in the 3' direction | |
| Synonyms |
|
|
| Definitions |
has a Stoichiometric coefficient of 2 Following peptide bond formation, GTP-bound eEF2 catalyzes the translocation of the deacylated tRNA in the P-site and the peptidyl-tRNA in the A-site (the pre-translocation state) into the E- and P- sites (the post-translocation state), respectively. Thus, the mRNA advances by three bases to expose the next codon in the A-site. After translocation, GDP-bound eEF2 leaves the ribosome to allow another round of elongation. eEF2 is reactivated by the release of GDP and binds GTP for subsequent rounds. <br>This process is illustrated below with a peptidyl-tRNA with a growing peptide, a deacylated tRNA with an -OH and a ribosome with A,P and E sites to accommodate these three forms of tRNA is also shown. Authored: Gopinathrao, G, 2005-02-08 19:10:56 |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0014834 |
|
| comment |
has a Stoichiometric coefficient of 2 Following peptide bond formation, GTP-bound eEF2 catalyzes the translocation of the deacylated tRNA in the P-site and the peptidyl-tRNA in the A-site (the pre-translocation state) into the E- and P- sites (the post-translocation state), respectively. Thus, the mRNA advances by three bases to expose the next codon in the A-site. After translocation, GDP-bound eEF2 leaves the ribosome to allow another round of elongation. eEF2 is reactivated by the release of GDP and binds GTP for subsequent rounds. <br>This process is illustrated below with a peptidyl-tRNA with a growing peptide, a deacylated tRNA with an -OH and a ribosome with A,P and E sites to accommodate these three forms of tRNA is also shown. Authored: Gopinathrao, G, 2005-02-08 19:10:56
|
|
| definition source |
Pubmed1620067 Reactome, http://www.reactome.org Pubmed1703007
|
|
| has input |
http://purl.obolibrary.org/obo/HINO_0013880 |
|
| has output |
http://purl.obolibrary.org/obo/CHEBI_18367 http://purl.obolibrary.org/obo/HINO_0013877 |
|
| label |
Translocation of ribosome by 3 bases in the 3' direction
|
|
| prefixIRI |
HINO:0014834
|
|
| prefLabel |
Translocation of ribosome by 3 bases in the 3' direction
|
|
| seeAlso |
ReactomeREACT_1937 Reactome Database ID Release 43156915
|
|
| subClassOf |
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |