Once the correct codon-anticodon match occurs between the mRNA and aa-tRNA, the decoding event triggers GTP hydrolysis on eEF1A. The resulting conformational change releases the aa-tRNA to the A-site, and GDP bound form eEF1A is released from the ribosome.<br>Insight into the mechanics of this system has been obtained from earlier works with rabbit reticulocytes and the E.coli system.<br>This process is illustrated below with: an amino acyl-tRNA with an amino acid, a peptidyl-tRNA with a growing peptide and a ribosome with A,P and E sites to accommodate these two forms of tRNA. Authored: Gopinathrao, G, 2005-03-11 20:46:56

http://purl.obolibrary.org/obo/HINO_0014831

Once the correct codon-anticodon match occurs between the mRNA and aa-tRNA, the decoding event triggers GTP hydrolysis on eEF1A. The resulting conformational change releases the aa-tRNA to the A-site, and GDP bound form eEF1A is released from the ribosome.
Insight into the mechanics of this system has been obtained from earlier works with rabbit reticulocytes and the E.coli system.
This process is illustrated below with: an amino acyl-tRNA with an amino acid, a peptidyl-tRNA with a growing peptide and a ribosome with A,P and E sites to accommodate these two forms of tRNA.

Authored: Gopinathrao, G, 2005-03-11 20:46:56

Reactome, http://www.reactome.org

Pubmed8722040

http://purl.obolibrary.org/obo/HINO_0013382

http://purl.obolibrary.org/obo/HINO_0013880

http://purl.obolibrary.org/obo/HINO_0013875

Aminoacyl-tRNA binds to the ribosome at the A-site

HINO:0014831

Aminoacyl-tRNA binds to the ribosome at the A-site

Reactome Database ID Release 43156907

ReactomeREACT_2075

http://purl.obolibrary.org/obo/INO_0000040