loading...| Preferred Name | eIF2:GTP is hydrolyzed, eIFs are released | |
| Synonyms |
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| Definitions |
Once the Met-tRNAi has recognized the AUG, eIF2-bound GTP is hydrolyzed. The reaction is catalyzed by eIF5 (or eIF5B) and is thought to cause dissociation of all other initiation factors and allow joining of the large 60S ribosomal subunit. Release of the initiation factors from 40S leaves the Met-tRNAi in the ribosomal P-site base-paired to the start codon on the mRNA. |
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| ID |
http://purl.obolibrary.org/obo/HINO_0014825 |
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| comment |
Once the Met-tRNAi has recognized the AUG, eIF2-bound GTP is hydrolyzed. The reaction is catalyzed by eIF5 (or eIF5B) and is thought to cause dissociation of all other initiation factors and allow joining of the large 60S ribosomal subunit. Release of the initiation factors from 40S leaves the Met-tRNAi in the ribosomal P-site base-paired to the start codon on the mRNA. |
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| definition source |
Pubmed11018020 Pubmed1095581 Pubmed429297 Pubmed1856230 Reactome, http://www.reactome.org Pubmed641056 Pubmed10659855 Pubmed592399 Pubmed592398 |
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| has input |
http://purl.obolibrary.org/obo/HINO_0013417 |
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| has output |
http://purl.obolibrary.org/obo/HINO_0013275 http://purl.obolibrary.org/obo/UniProt_P23588 http://purl.obolibrary.org/obo/UniProt_Q04637 http://purl.obolibrary.org/obo/HINO_0013418 http://purl.obolibrary.org/obo/HINO_0013420 http://purl.obolibrary.org/obo/UniProt_Q15056 http://purl.obolibrary.org/obo/UniProt_P06730 http://purl.obolibrary.org/obo/CHEBI_18367 http://purl.obolibrary.org/obo/HINO_0013268 |
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| label |
eIF2:GTP is hydrolyzed, eIFs are released |
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| prefixIRI |
HINO:0014825 |
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| prefLabel |
eIF2:GTP is hydrolyzed, eIFs are released |
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| seeAlso |
Reactome Database ID Release 4372619 ReactomeREACT_1060 |
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| subClassOf |