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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Id | http://purl.obolibrary.org/obo/HINO_0014626
http://purl.obolibrary.org/obo/HINO_0014626
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|---|---|
| Preferred Name | Translation and translocation of ATF4 |
| Definitions |
Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31
Reviewed: Urano, F, 2010-04-30
Authored: May, B, 2009-06-02 00:51:49
Edited: May, B, 2009-06-02 00:51:49
Phosphorylation of eIF2-alpha causes increased translation of ATF4 mRNA. In mouse the mRNA of ATF4 contains 2 upstream ORFs (uORFs) (Vattem and Wek 2004). The second uORF overlaps the ORF encoding ATF4 and thus prevents translation of ATF4. When eIF2-alpha is phosphorylated, translation of the uORFs is suppressed and translation of the ORF encoding ATF4 is increased.
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Translation and translocation of ATF4
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|---|---|
| comment |
Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31
Reviewed: Urano, F, 2010-04-30
Authored: May, B, 2009-06-02 00:51:49
Edited: May, B, 2009-06-02 00:51:49
Phosphorylation of eIF2-alpha causes increased translation of ATF4 mRNA. In mouse the mRNA of ATF4 contains 2 upstream ORFs (uORFs) (Vattem and Wek 2004). The second uORF overlaps the ORF encoding ATF4 and thus prevents translation of ATF4. When eIF2-alpha is phosphorylated, translation of the uORFs is suppressed and translation of the ORF encoding ATF4 is increased.
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| prefLabel |
Translation and translocation of ATF4
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| definition source |
Pubmed18426796
Reactome, http://www.reactome.org
Pubmed15314157
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| prefixIRI |
HINO:0014626
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| seeAlso |
Reactome Database ID Release 43381128
ReactomeREACT_18270
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| subClassOf | |
| type |
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