loading...| Preferred Name |
Translation and translocation of ATF4 |
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Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31 Reviewed: Urano, F, 2010-04-30 Authored: May, B, 2009-06-02 00:51:49 Edited: May, B, 2009-06-02 00:51:49 Phosphorylation of eIF2-alpha causes increased translation of ATF4 mRNA. In mouse the mRNA of ATF4 contains 2 upstream ORFs (uORFs) (Vattem and Wek 2004). The second uORF overlaps the ORF encoding ATF4 and thus prevents translation of ATF4. When eIF2-alpha is phosphorylated, translation of the uORFs is suppressed and translation of the ORF encoding ATF4 is increased. |
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| ID |
http://purl.obolibrary.org/obo/HINO_0014626 |
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| comment |
Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31 Reviewed: Urano, F, 2010-04-30 Authored: May, B, 2009-06-02 00:51:49 Edited: May, B, 2009-06-02 00:51:49 Phosphorylation of eIF2-alpha causes increased translation of ATF4 mRNA. In mouse the mRNA of ATF4 contains 2 upstream ORFs (uORFs) (Vattem and Wek 2004). The second uORF overlaps the ORF encoding ATF4 and thus prevents translation of ATF4. When eIF2-alpha is phosphorylated, translation of the uORFs is suppressed and translation of the ORF encoding ATF4 is increased. |
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| definition source |
Pubmed18426796 Reactome, http://www.reactome.org Pubmed15314157 |
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Translation and translocation of ATF4 |
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HINO:0014626 |
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Translation and translocation of ATF4 |
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Reactome Database ID Release 43381128 ReactomeREACT_18270 |
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