loading...| Preferred Name | Integrin alpha2beta1 collagen adhesion | |
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| Definitions |
Integrin Alpha2 Beta1, known on leukocytes as VLA-2, is the major platelet collagen receptor (Kunicki et al. 1988). It requires Mg2+ to interact with collagen and may require initiation mediated by the activation of AlphaIIbBeta3 (van de Walle 2007). Binding occurs via the alpha2 subunit I domain to a collagen motif with the sequence Gly-Phe-Hyp-Gly-Glu-Arg (Emsley 2000). Binding of collagen to Alpha2 Beta1 generates the intracellular signals that contribute to platelet activation. Authored: Geiger, B, Horwitz, R, 2008-05-07 08:30:32 Reviewed: Yamada, K, Humphries, MJ, Hynes, R, 2008-05-07 08:53:37 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0014507 |
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| comment |
Integrin Alpha2 Beta1, known on leukocytes as VLA-2, is the major platelet collagen receptor (Kunicki et al. 1988). It requires Mg2+ to interact with collagen and may require initiation mediated by the activation of AlphaIIbBeta3 (van de Walle 2007). Binding occurs via the alpha2 subunit I domain to a collagen motif with the sequence Gly-Phe-Hyp-Gly-Glu-Arg (Emsley 2000). Binding of collagen to Alpha2 Beta1 generates the intracellular signals that contribute to platelet activation. Authored: Geiger, B, Horwitz, R, 2008-05-07 08:30:32 Reviewed: Yamada, K, Humphries, MJ, Hynes, R, 2008-05-07 08:53:37 |
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| definition source |
Pubmed16985184 Reactome, http://www.reactome.org Pubmed10778855 Pubmed2832397 |
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| has input |
http://purl.obolibrary.org/obo/CHEBI_18420 |
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| label |
Integrin alpha2beta1 collagen adhesion |
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| prefixIRI |
HINO:0014507 |
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| prefLabel |
Integrin alpha2beta1 collagen adhesion |
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| seeAlso |
ReactomeREACT_1990 Reactome Database ID Release 43114563 |
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