Human Interaction Network Ontology

Last uploaded: June 27, 2014
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Id http://purl.obolibrary.org/obo/HINO_0014457
http://purl.obolibrary.org/obo/HINO_0014457
Preferred Name

STIM1 activation of CRAC
Definitions
has a Stoichiometric coefficient of 2 Sustained calcium signalling in lymphocytes and platelets requires the uptake of extracellular calcium when intracellular stores are depleted. The process whereby intracellular calcium depletion stimulates calcium uptake is often referred to as Store-operated calcium entry (SOCE). Store depletion is sensed by stromal interaction molecule 1 (STIM1), which then translocates to the plasma membrane and associates with 2 dimers of Orai1 to form a calcium-release activated calcium (CRAC) channel. Authored: Akkerman, JW, 2009-09-04 Edited: Jupe, S, 2010-06-07 Reviewed: Kunapuli, SP, 2010-06-07
Type http://www.w3.org/2002/07/owl#Class

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label
STIM1 activation of CRAC
comment
has a Stoichiometric coefficient of 2
Sustained calcium signalling in lymphocytes and platelets requires the uptake of extracellular calcium when intracellular stores are depleted. The process whereby intracellular calcium depletion stimulates calcium uptake is often referred to as Store-operated calcium entry (SOCE). Store depletion is sensed by stromal interaction molecule 1 (STIM1), which then translocates to the plasma membrane and associates with 2 dimers of Orai1 to form a calcium-release activated calcium (CRAC) channel.
Authored: Akkerman, JW, 2009-09-04
Edited: Jupe, S, 2010-06-07
Reviewed: Kunapuli, SP, 2010-06-07
prefLabel
STIM1 activation of CRAC
definition source
Pubmed18952890
Pubmed18187424
Reactome, http://www.reactome.org
Pubmed19249086
Pubmed17703229
Pubmed17965774
Pubmed18769136
Pubmed18596693
Pubmed16921385
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prefixIRI
HINO:0014457
seeAlso
ReactomeREACT_23904
Reactome Database ID Release 43434700
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