loading...| Preferred Name | Chondroitin sulfate/dermatan sulfate metabolism | |
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| Definitions |
Chondroitin sulfate (CS) is a sulfated glycosaminoglycan (GAG). CS chains are unbranched polysaccharides of varying length containing two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc). The chains are usually attached to proteins forming a proteoglycan. CS is an important structural component of cartilage due to it's ability to withstand compression. It is also a widely used dietary supplement for osteoarthritis. When some of the GlcA residues are epimerized into L-iduronic acid (IdoA) the resulting disaccharide is then referred to as dermatan sulfate (DS) (Silbert & Sugumaran 2002). DS is the most predominant GAG in skin but is also found in blood vessels, heart valves, tendons, and the lungs. It may play roles in cardiovascular disease, tumorigenesis, infection, wound repair and fibrosis (Trowbridge & Gallo 2002). Reviewed: D'Eustachio, P, 2012-03-28 Edited: Jassal, B, 2011-10-21 Authored: Jassal, B, 2011-10-21 |
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| ID |
http://purl.obolibrary.org/obo/HINO_0014095 |
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| comment |
Chondroitin sulfate (CS) is a sulfated glycosaminoglycan (GAG). CS chains are unbranched polysaccharides of varying length containing two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc). The chains are usually attached to proteins forming a proteoglycan. CS is an important structural component of cartilage due to it's ability to withstand compression. It is also a widely used dietary supplement for osteoarthritis. When some of the GlcA residues are epimerized into L-iduronic acid (IdoA) the resulting disaccharide is then referred to as dermatan sulfate (DS) (Silbert & Sugumaran 2002). DS is the most predominant GAG in skin but is also found in blood vessels, heart valves, tendons, and the lungs. It may play roles in cardiovascular disease, tumorigenesis, infection, wound repair and fibrosis (Trowbridge & Gallo 2002). Reviewed: D'Eustachio, P, 2012-03-28 Edited: Jassal, B, 2011-10-21 Authored: Jassal, B, 2011-10-21 |
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| definition source |
Pubmed17239764 Pubmed12512856 Reactome, http://www.reactome.org Pubmed12213784 |
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| label |
Chondroitin sulfate/dermatan sulfate metabolism |
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| prefixIRI |
HINO:0014095 |
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| prefLabel |
Chondroitin sulfate/dermatan sulfate metabolism |
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| seeAlso |
GENE ONTOLOGYGO:0030204 ReactomeREACT_121206 Reactome Database ID Release 431793185 |
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| subClassOf | ||
| has_part |
http://purl.obolibrary.org/obo/HINO_0014094 http://purl.obolibrary.org/obo/HINO_0014093 |