Authored: Orlic-Milacic, Marija, 2011-06-14 Reviewed: MacPherson, D, 2011-08-25 has a Stoichiometric coefficient of 3 At G1 entry from G0, p130 (RBL2) is phosphorylated on three threonine and serine residues by cyclin D1 dependent kinases CDK4 and/or CDK6, leading to dissociation of p130 (RBL2) from complexes it formed with E2F4 or E2F5 and DP1 or DP2. This is thought to promote translocation of E2F4 and E2F5, which lack nuclear localization signals, to the cytosol, allowing activating E2Fs (E2F1, E2F2 and E2F3) to bind E2F promoters and activate transcription of genes needed for G1 progression.

http://purl.obolibrary.org/obo/HINO_0011423

Authored: Orlic-Milacic, Marija, 2011-06-14

Reviewed: MacPherson, D, 2011-08-25

has a Stoichiometric coefficient of 3

At G1 entry from G0, p130 (RBL2) is phosphorylated on three threonine and serine residues by cyclin D1 dependent kinases CDK4 and/or CDK6, leading to dissociation of p130 (RBL2) from complexes it formed with E2F4 or E2F5 and DP1 or DP2. This is thought to promote translocation of E2F4 and E2F5, which lack nuclear localization signals, to the cytosol, allowing activating E2Fs (E2F1, E2F2 and E2F3) to bind E2F promoters and activate transcription of genes needed for G1 progression.

Reactome, http://www.reactome.org

Pubmed11157749

Pubmed9144196

http://purl.obolibrary.org/obo/HINO_0024322

http://purl.obolibrary.org/obo/CHEBI_15422

http://purl.obolibrary.org/obo/UniProt_Q08999

http://purl.obolibrary.org/obo/HINO_0022807

http://purl.obolibrary.org/obo/CHEBI_16761

Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex

HINO:0011423

Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex

Reactome Database ID Release 431226094

EC Number: 2.7.11.22

ReactomeREACT_111206

http://purl.obolibrary.org/obo/INO_0000040