Link to this page
Human Interaction Network Ontology
Last uploaded:
June 27, 2014
Jump to:
| Preferred Name | Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex | |
| Synonyms |
|
|
| Definitions |
Authored: Orlic-Milacic, Marija, 2011-06-14 has a Stoichiometric coefficient of 4 Reviewed: MacPherson, D, 2011-08-25 In late G1, cyclin D dependent kinases CDK4 and CDK6 phosphorylate RBL1 (p107) on four serine and threonine residues (S964, S975, T369 and S640), leading to dissociation of phosphorylated RBL1 (p107) from E2F4 in complex with either DP-1 or DP-2. E2F4, which lacks nuclear localization signal, is then thought to translocate to the cytosol, allowing E2F promoter sites to become occupied by activating E2Fs (E2F1, E2F2, and E2F3), resulting in transcription of E2F targets needed for cell cycle progression. |
|
| ID |
http://purl.obolibrary.org/obo/HINO_0011419 |
|
| comment |
Authored: Orlic-Milacic, Marija, 2011-06-14 has a Stoichiometric coefficient of 4 Reviewed: MacPherson, D, 2011-08-25 In late G1, cyclin D dependent kinases CDK4 and CDK6 phosphorylate RBL1 (p107) on four serine and threonine residues (S964, S975, T369 and S640), leading to dissociation of phosphorylated RBL1 (p107) from E2F4 in complex with either DP-1 or DP-2. E2F4, which lacks nuclear localization signal, is then thought to translocate to the cytosol, allowing E2F promoter sites to become occupied by activating E2Fs (E2F1, E2F2, and E2F3), resulting in transcription of E2F targets needed for cell cycle progression.
|
|
| definition source |
Pubmed11884610 Reactome, http://www.reactome.org Pubmed9144196 Pubmed7797074
|
|
| has input | ||
| has output |
http://purl.obolibrary.org/obo/UniProt_P28749 |
|
| label |
Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex
|
|
| prefixIRI |
HINO:0011419
|
|
| prefLabel |
Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex
|
|
| seeAlso |
Reactome Database ID Release 431226095 EC Number: 2.7.11.22 ReactomeREACT_111248
|
|
| subClassOf |
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |