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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | Ubiquitination of p130 (RBL2) by SCF (Skp2) | |
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| Definitions |
Authored: Orlic-Milacic, Marija, 2011-06-14 Reviewed: MacPherson, D, 2011-08-25 As quiescent G0 cells reenter the cell cycle, p130 (RBL2) is phosphorylated by CDK4/6. This phosphorylated p130 (RBL2) binds ubiquitin ligase SCF (Skp2) in complex with Cks1, and is subsequently ubiquitinated and degraded similarly to p27, which is another target of SCF (Skp2). |
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http://purl.obolibrary.org/obo/HINO_0011411 |
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| comment |
Authored: Orlic-Milacic, Marija, 2011-06-14 Reviewed: MacPherson, D, 2011-08-25 As quiescent G0 cells reenter the cell cycle, p130 (RBL2) is phosphorylated by CDK4/6. This phosphorylated p130 (RBL2) binds ubiquitin ligase SCF (Skp2) in complex with Cks1, and is subsequently ubiquitinated and degraded similarly to p27, which is another target of SCF (Skp2).
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| definition source |
Reactome, http://www.reactome.org Pubmed12435635
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Ubiquitination of p130 (RBL2) by SCF (Skp2)
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HINO:0011411
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| prefLabel |
Ubiquitination of p130 (RBL2) by SCF (Skp2)
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EC Number: 6.3.2.19 ReactomeREACT_111089 Reactome Database ID Release 431363331
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