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Human Interaction Network Ontology
Last uploaded:
June 27, 2014
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| Preferred Name | p130 (RBL2) binds Cyclin E/A:CDK2 | |
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| Definitions |
Authored: Orlic-Milacic, Marija, 2011-06-14 Reviewed: MacPherson, D, 2011-08-25 p130 (RBL2) is able to bind complexes of CDK2 with either cyclin A or cyclin E through the cyclin-binding LFG motif within the pocket domain, which is conserved in p107 (RBL1) and p21/WAF1/Cip1 family of cyclin-dependent kinases. In addition to LFG motif, amino terminal region of p130 (RBL2), conserved in p107 (RBL1), is necessary for inhibition of CDK2 kinase activity. Presence of E2F is not required for this interaction. |
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| ID |
http://purl.obolibrary.org/obo/HINO_0011353 |
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| comment |
Authored: Orlic-Milacic, Marija, 2011-06-14 Reviewed: MacPherson, D, 2011-08-25 p130 (RBL2) is able to bind complexes of CDK2 with either cyclin A or cyclin E through the cyclin-binding LFG motif within the pocket domain, which is conserved in p107 (RBL1) and p21/WAF1/Cip1 family of cyclin-dependent kinases. In addition to LFG motif, amino terminal region of p130 (RBL2), conserved in p107 (RBL1), is necessary for inhibition of CDK2 kinase activity. Presence of E2F is not required for this interaction.
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| definition source |
Reactome, http://www.reactome.org Pubmed9199292
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| label |
p130 (RBL2) binds Cyclin E/A:CDK2
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| prefixIRI |
HINO:0011353
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| prefLabel |
p130 (RBL2) binds Cyclin E/A:CDK2
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| seeAlso |
ReactomeREACT_111079 Reactome Database ID Release 431363306
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