loading...| Preferred Name | Assembly of EGFR complex in clathrin-coated vesicles | |
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| Definitions |
Reviewed: Heldin, CH, 2008-02-12 09:44:02 CBl-CIN85-Endophilin complex mediates ligand-induced down-regulation of the EGF receptor. The BAR domain of endophilin induces membrane curvature. The three SH3 domains of CIN85 bind to atypical proline-arginine motifs (PxxxPR) present in the carboxyl termini of CBL and CBL-b. In this way, CIN85 clusters CBL molecules, which is crucial for efficient EGFR endocytosis and degradation. Authored: Castagnoli, L, 2006-10-10 13:09:34 |
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http://purl.obolibrary.org/obo/HINO_0009876 |
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Reviewed: Heldin, CH, 2008-02-12 09:44:02 CBl-CIN85-Endophilin complex mediates ligand-induced down-regulation of the EGF receptor. The BAR domain of endophilin induces membrane curvature. The three SH3 domains of CIN85 bind to atypical proline-arginine motifs (PxxxPR) present in the carboxyl termini of CBL and CBL-b. In this way, CIN85 clusters CBL molecules, which is crucial for efficient EGFR endocytosis and degradation. Authored: Castagnoli, L, 2006-10-10 13:09:34 |
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| definition source |
Reactome, http://www.reactome.org Pubmed11894095 |
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Assembly of EGFR complex in clathrin-coated vesicles |
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HINO:0009876 |
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Assembly of EGFR complex in clathrin-coated vesicles |
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Reactome Database ID Release 43182994 ReactomeREACT_12521 |
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